Sequential Retro-Ene Arylation Reaction of N-Alkoxyenamides for the Synthesis of tert-Alkylamines
Sequential Retro-Ene Arylation Reaction of N-Alkoxyenamides for the Synthesis of tert-Alkylamines
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DOI：
10.1021/ol4014238
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发表时间：
2013-07-05
期刊：
影响因子：
5.2
通讯作者：
Miyata, Okiko
中科院分区：
文献类型：
--
作者：
Miyoshi, Tetsuya;Matsuya, Syota;Miyata, Okiko
通过将三芳基铝试剂亲核加成到原位生成的 N-酰基酮亚胺上，开发了连续逆烯基芳基化反应，以良好的产率将 N-烷氧基烯酰胺转化为相应的叔烷基胺。该反应能够耐受一系列官能团，并且可以轻松获得一系列叔烷基胺，而使用常规方法很难获得这些叔烷基胺。
A sequential retro-ene arylation reaction has been developed for the conversion of N-alkoxyenamides to the corresponding tert-alkylamines in good yields via the nucleophilic addition of a triarylaluminum reagent to an in situ generated N-acylketimine. The reaction is tolerant of a range of functional groups and provides facile access to a series of tert-alkylamines that would be otherwise difficult to access using conventional procedures.