Synthesis, in vitro hydroxyapatite forming ability, and cytocompatibility of strontium silicate powders
Synthesis, in vitro hydroxyapatite forming ability, and cytocompatibility of strontium silicate powders
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硅酸锶粉末的合成、体外羟基磷灰石形成能力及细胞相容性
DOI：
10.1002/jbm.b.31582
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发表时间：
2010-04-01
影响因子：
3.4
通讯作者：
Chang, Jiang
中科院分区：
文献类型：
--
作者：
Zhang, Meili;Zhai, Wanyin;Chang, Jiang
采用化学沉淀法合成了纯相硅酸锶（SrSiO 3）粉体。通过考察粉体表面在模拟体液中浸泡不同时间后羟基磷灰石的形成能力，评价粉体的体外生物活性。结果表明，SrSiO 3在浸泡7 d后可诱导羟基碳酸磷灰石的形成。采用L929和兔骨髓基质细胞（rMSCs）对SrSiO 3进行体外细胞相容性测试。L929培养实验表明，SrSiO 3的离子产物除了在高离子浓度（Si 3.75 mM和Sr 0.12 mM）下外，不显示细胞毒性。此外，在一定的离子浓度（Si 1.87-0.12 mM和Sr 0.12-3.75 x 10（-3）mM）下，SrSiO 3的离子产物刺激rMSCs的增殖。这些结果表明，SrSiO 3可能是一种新的生物活性骨再生材料的应用。(C)2010 Wiley Periodicals，Inc.生物医学材料研究杂志B部分：应用生物材料93 B：252-257，2010年
Phase-pure strontium silicate (SrSiO3) powders were synthesized by chemical precipitation method. In vitro bioactivity of the powders were evaluated by examining the hydroxyapatite forming ability on their surface soaking simulated body fluid for various periods. The results showed that SrSiO3 could induce hydroxy carbonate apatite formation after soaking for 7 days. Both L929 and rabbit bone marrow stromal cells (rMSCs) were used to test the in vitro cytocompatibility of SrSiO3. L929 culture experiment showed that the ionic product of SrSiO3 did not exhibit cytotoxicity except at high ion concentrations (Si 3.75 mM and Sr 0.12 mM). Moreover, at certain ion concentrations (Si 1.87-0.12 mM and Sr 0.12-3.75 x 10(-3) mM), the ionic product of SrSiO3 stimulated the proliferation of rMSCs. All the results indicated that SrSiO3 might be used as a new bioactive material for bone regeneration applications. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 93B: 252-257, 2010