The influence of weather on the risk of pain exacerbation in patients with knee osteoarthritis - a case-crossover study
The influence of weather on the risk of pain exacerbation in patients with knee osteoarthritis - a case-crossover study
复制标题
DOI：
10.1016/j.joca.2016.07.016
复制
发表时间：
2016-12-01
影响因子：
7
通讯作者：
Hunter, D. J.
中科院分区：
文献类型：
--
作者：
Ferreira, M. L.;Zhang, Y.;Hunter, D. J.
目的：量化膝骨关节炎患者与温度、相对湿度、气压和降水相关的膝关节疼痛恶化风险。方法：进行了基于网络的病例交叉研究。对诊断为有症状的放射学膝骨关节炎的参与者进行基线测量并随访 3 个月。如果参与者认为膝盖疼痛加剧（危险期），则指示他们登录研究网站。疼痛加剧被定义为在 0-10 数字评分量表 (NRS) 上，参与者在基线报告的最轻微疼痛增加≥2。进行了时间分层病例交叉研究，将相应的危险日期固定到特定 35 天间隔内的四个控制期。灾害和控制期间的最高和最低温度（摄氏度）、相对湿度（%）、气压（hPa）和降水量（毫米）数据是从澳大利亚气象局公开的气象数据库中获得的。使用条件逻辑回归评估这些关联。结果：在招募的 345 名参与者中，171 名参与者（女性：64%，平均年龄：62 岁，平均 BMI：30.2 kg/m(2)）经历了至少一次疼痛加剧，分析中包含了 1,425 个观察结果。温度、相对湿度、气压或降水量与膝关节疼痛加剧的风险之间没有明显关联。结论：尽管有患者的轶事报道，但天气因素的变化似乎并不影响膝骨关节炎患者疼痛加剧的风险。其他研究应该量化极端天气条件地区的天气与疼痛加剧风险之间的关系。 (C) 2016 年国际骨关节炎研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To quantify the risk of knee pain exacerbation associated with temperature, relative humidity, air pressure and precipitation in persons with knee osteoarthritis.Method: A web-based case-crossover study was conducted. Participants with a diagnosis of symptomatic, radiographic knee osteoarthritis were measured at baseline and followed for 3 months. Participants were instructed to log on to the study website if they perceived experiencing knee pain exacerbation (hazard period). Pain exacerbation was defined as an increase of >= 2 on a 0-10 numeric rating scale (NRS) from the participant's mildest pain reported at baseline. A time-stratified case-crossover study was conducted to anchor the corresponding hazard date to four control periods within a particular 35-day interval. Data on maximum and minimum temperature (degrees C), relative humidity (%), barometric pressure (hPa) and precipitation (mm) were obtained for the hazard and control periods from the publicly available meteorological database of the Australian Bureau of Meteorology. The associations were assessed using conditional logistic regression.Results: Of the 345 participants recruited, 171 participants (women: 64%, mean age: 62 years, mean BMI: 30.2 kg/m(2)) experienced at least one episode of pain exacerbation, yielding 1,425 observations included in the analyses. There was no apparent association between temperature, relative humidity, air pressure or precipitation and risk of knee pain exacerbation.Conclusion: Despite anecdotal reports from patients, change in weather factors does not appear to influence the risk of pain exacerbation in persons with knee osteoarthritis. Additional studies should quantify the association of weather and risk of pain exacerbation in regions with more extreme weather conditions. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.