A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling.
A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling.
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DDX3X在DSRNA衍生的先天免疫信号传导中的双重作用。
DOI：
10.3389/fmolb.2022.912727
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
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DEAD-Box Helicase 3 X-Linked（DDX 3X）是RNA代谢所必需的，参与各种涉及RNA的细胞过程。DDX 3X与癌症生长和转移有关。DDX 3X参与病毒RNA的抗病毒反应，并有助于促微生物或抗微生物反应。更好地理解人类细胞如何调节针对病毒“非自身”双链RNA（dsRNA）和内源性病毒样“自身”dsRNA的先天免疫应答对于理解先天免疫感测、抗微生物免疫、炎症、免疫细胞稳态以及开发用于感染性、免疫介导的疾病和癌症的新疗法至关重要。DDX 3X已知可激活病毒dsRNA传感途径和先天免疫。然而，越来越多的研究揭示了DDX 3X在调节细胞中dsRNA介导的信号传导中的更复杂的作用。在这里，我们讨论了DDX 3X在病毒dsRNA或内源性dsRNA介导的免疫信号通路中的作用。
DEAD-Box Helicase 3 X-Linked (DDX3X) is essential for RNA metabolism and participates in various cellular processes involving RNA. DDX3X has been implicated in cancer growth and metastasis. DDX3X is involved in antiviral responses for viral RNAs and contributes to pro- or anti-microbial responses. A better understanding of how human cells regulate innate immune response against the viral “non-self” double-stranded RNAs (dsRNAs) and endogenous viral-like “self” dsRNAs is critical to understanding innate immune sensing, anti-microbial immunity, inflammation, immune cell homeostasis, and developing novel therapeutics for infectious, immune-mediated diseases, and cancer. DDX3X has known for activating the viral dsRNA-sensing pathway and innate immunity. However, accumulating research reveals a more complex role of DDX3X in regulating dsRNA-mediated signaling in cells. Here, we discuss the role of DDX3X in viral dsRNA- or endogenous dsRNA-mediated immune signaling pathways.