Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls.
Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls.
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DOI：
10.1021/acs.orglett.6b01871
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发表时间：
2016-08
期刊：
影响因子：
5.2
通讯作者：
Chenyang Wang;Yabo Li;M. Gong;Qi Wu;Jianye Zhang;J. K. Kim;Mengmeng Huang;Yangjie Wu
中科院分区：
文献类型：
--
作者：
Chenyang Wang;Yabo Li;M. Gong;Qi Wu;Jianye Zhang;J. K. Kim;Mengmeng Huang;Yangjie Wu
本文提出了一种以不活泼的乙腈和简单的1，3-二羰基化合物为原料合成α-氰甲基-β-二羰基化合物的新方法。根据对照实验的电喷雾质谱分析结果，提出了自由基机理。
A novel and efficient method for the synthesis of α-cyanomethyl-β-dicarbonyls in moderate to excellent yields is developed by using inactive CH3CN and simple 1,3-dicarbonyls. A radical mechanism is proposed under the ESI-MS (electrospray ionization mass spectrometry) analysis results of control experiments.