Stability Properties of Photopolymerized Liposomes
Stability Properties of Photopolymerized Liposomes
复制标题
光聚合脂质体的稳定性能
DOI：
10.1038/nbt1283-882
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. Singh
中科院分区：
文献类型：
--
作者：
R. Juliano;S. Regen;M. Singh;M. Hsu;A. Singh
脂质囊泡（脂质体）可由[1，2-（甲基丙烯酰氧基）十二烷酰基]-L-α-磷脂酰胆碱（磷脂酰胆碱的光聚合类似物）形成。与常规脂质体相比，光聚合囊泡显示出增强的机械稳定性和亲脂性化合物的增强的保留。因此，虽然去污剂溶解常规囊泡并释放掺入的亲脂性标记物如胆固醇油酸酯，但光聚合的囊泡即使在极高的去污剂浓度下也保留亲脂性化合物。光聚合囊泡可证明在亲水性和亲脂性药物的制剂和受控递送的某些方面是有用的。
Lipid vesicles (liposomes) can be formed from [1,2–(methacryloyloxy)dodecanoyl]–L–α–phosphatidylcholine, a photopolymerizable analog of phosphatidylcholine. As compared to conventional liposomes, the photopolymerized vesicles display enhanced mechanical stability and enhanced retention of lipophilic compounds. Thus, while detergents solubilize conventional vesicles and release incorporated lipophilic markers such as cholesterol oleate, the photopolymerized vesicles retain lipophilic compounds even at extremely high detergent concentrations. Photopolymerized vesicles may prove to be useful in certain aspects of the formulation and controlled delivery of hydrophilic and lipophilic drugs.