Development of novel behavioral interventions in an experimental therapeutics world: Challenges, and directions for the future.
Development of novel behavioral interventions in an experimental therapeutics world: Challenges, and directions for the future.
复制标题
实验治疗领域新型行为干预的发展：挑战和未来方向。
DOI：
10.1016/j.schres.2017.06.010
复制
发表时间：
2018
影响因子：
4.5
通讯作者：
Keshavan,MatcheriS
中科院分区：
文献类型：
--
作者：
Lewandowski,KathrynE;Ongur,Dost;Keshavan,MatcheriS
最近，与临床试验相关的资助机制的重点已经改变为与实验治疗方法一致。虽然这种方法具有相当大的前景，但范式转变对复杂精神疾病（如精神分裂症）的行为试验提出了挑战，因为分子靶标——实验治疗范式的经典焦点——可能不代表许多旨在治疗多方面、多重确定症状的社会心理干预的逻辑靶标。目前还没有提供替代模型的明确指导方针，这使得大量临床试验研究人员不清楚如何构建他们的工作。我们解决了行为干预研究的一些挑战，并为将目标参与框架应用于行为临床试验的新方法的开发提供了指导。
Recently, the focus of funding mechanisms associated with clinical trials has changed to be consistent with an experimental therapeutics approach. While this approach holds considerable promise, the paradigm shift has presented challenges for behavioral trials in complex psychiatric illness such as schizophrenia, as molecular targets – the classic focus in experimental therapeutics paradigms – may not represent logical targets for many psychosocial interventions designed to treat multifaceted, multiply determined symptoms. Clear guidelines for alternate models have not been offered, leaving large numbers of clinical trials researchers unclear about how to frame their work. We address some of the challenges for behavioral interventions research, and offer guidance for the development of novel approaches to the application of a target engagement framework to behavioral clinical trials.