IN THE CLUTCHES OF PROTEOGLYCANS - HOW DOES HEPARAN-SULFATE REGULATE FGF BINDING
IN THE CLUTCHES OF PROTEOGLYCANS - HOW DOES HEPARAN-SULFATE REGULATE FGF BINDING
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DOI：
10.1016/1074-5521(95)90025-x
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发表时间：
1995-10-01
影响因子：
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通讯作者：
RAPRAEGER, AC
中科院分区：
文献类型：
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作者：
RAPRAEGER, AC
成纤维细胞生长因子及其受体与硫酸乙酰肝素糖胺聚糖结合。这被认为促进配体-受体结合并通过促进受体多聚化来增强信号传导。设计用于占据这些结合位点的合成模拟物可以提供理解和调节FGF信号传导的手段。
Fibroblast growth factors and their receptors bind to heparan sulfate glycosaminoglycans. This is thought to promote ligand-receptor binding and enhance signaling by promoting receptor multimerization. Synthetic mimetics designed to occupy these binding sites may provide the means to understand and to regulate FGF signaling.