The relationship between circulating irisin levels and endothelial function in lean and obese subjects
The relationship between circulating irisin levels and endothelial function in lean and obese subjects
复制标题
瘦和肥胖受试者循环鸢尾素水平与内皮功能之间的关系。
DOI：
10.1111/cen.12658
复制
发表时间：
2015-09-01
影响因子：
3.2
通讯作者：
Sun, Xiaodong
中科院分区：
文献类型：
--
作者：
Hou, Ningning;Han, Fang;Sun, Xiaodong
已经显示，鸢尾素将白色脂肪细胞转变为棕色样脂肪细胞，这正在成为肥胖症的有吸引力的治疗靶点。本研究的目的是确定是否循环鸢尾素水平与内皮功能障碍在肥胖subjects.DesignA共41非高血压，非糖尿病肥胖受试者和40年龄和性别匹配的瘦健康对照参与了这项研究。检测受试者的临床特征、血液生化、循环鸢尾素和脂联素。采用高分辨率超声测定内皮依赖性血管舒张功能（EDV）和内皮非依赖性血管舒张功能（EIV）。
ObjectiveIrisin has been shown to turn white adipocytes into brown-like adipocytes, which is emerging as an appealing therapeutic target for obesity. The objective of the study was to determine whether circulating irisin levels are related to endothelial dysfunction in obese subjects.DesignA total of 41 nonhypertensive, nondiabetic obese subjects and 40 age- and sex-matched lean healthy control were involved in this study. Clinical characteristics, blood biochemistry, circulating irisin and adiponectin of the subjects were measured. Endothelium-dependent vasodilation (EDV) and endothelial-independent vasodilation (EIV) were determined using high-resolution ultrasound.ResultsCirculating irisin and adiponectin were significantly lower in obese subjects compared with lean healthy control (P