The aggregation properties of some bradykinin analogs.
The aggregation properties of some bradykinin analogs.
复制标题
一些缓激肽类似物的聚集特性。
DOI：
10.1080/07391102.1993.10508715
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发表时间：
1993
影响因子：
4.4
通讯作者：
Kotovych,G
中科院分区：
文献类型：
--
作者：
Liu,X;Stewart,JM;Cann,JR;Gera,L;Kotovych,G
Bradykinin (BK) is a peptide hormone with sequence Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9and has been implicated in a multitude of pathophysiological processes such as the ability to lower systemic blood pressure and stimulate pain. Bulky, beta-branched D-aliphatic residues at position 7 combined with bulky L-aliphatic residues at position 8 have now been observed to yield strong antagonists. Nuclear magnetic resonance studies have been carried out on many of these molecules with a view to determining their solution conformations. However, two such analogs, namely DArg-[Hyp3, Thi5, DSer6, DCpg7, Cpg8]-BK [I] and DArg-[Hyp3, DSer6, DCpg7, Cpg8]-BK [II] (Cpg = α-cyclopentyl-glycine; Hyp = 4-hydroxy-L-proline, Thi = β-(2-thienyl)-L-alanine), have exhibited an abnormal, non-linear temperature dependence for the amide NH proton of Cpg8. The NH of Arg9also shows a slightly non-linear temperature dependence at higher temperatures above 25 °C. In addition, a very slow exchange rate for the NH protons of DCpg7, Cpg8and Arg9indicated aggregation of these two analogs, which was confirmed using the circular dichroism experiments.
