The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study.
The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study.
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DOI：
10.1017/s0033291723001071
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发表时间：
2023-11
影响因子：
6.9
通讯作者：
Di Forti, Marta
中科院分区：
文献类型：
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作者：
Spinazzola, Edoardo;Quattrone, Diego;Rodriguez, Victoria;Trotta, Giulia;Alameda, Luis;Tripoli, Giada;Gayer-Anderson, Charlotte;Freeman, Tom P.;Johnson, Emma C.;Jongsma, Hannah E.;Stilo, Simona;La Cascia, Caterina;Ferraro, Laura;La Barbera, Daniele;Lasalvia, Antonio;Tosato, Sarah;Tarricone, Ilaria;D'Andrea, Giuseppe;Galatolo, Michela;Tortelli, Andrea;Tagliabue, Ilaria;Turco, Marco;Pompili, Maurizio;Selten, Jean-Paul;de Haan, Lieuwe;Rossi Menezes, Paulo;Del Ben, Cristina M.;Santos, Jose Luis;Arrojo, Manuel;Bobes, Julio;Sanjuan, Julio;Bernardo, Miguel;Arango, Celso;Kirkbride, James B.;Jones, Peter B.;O'Donovan, Michael;Rutten, Bart P.;Van Os, Jim;Morgan, Craig;Sham, Pak C.;Austin-Zimmerman, Isabelle;Li, Zhikun;Vassos, Evangelos;Murray, Robin M.;Di Forti, Marta
虽然大麻使用是一个公认的精神病风险因素，但人们对首次使用大麻的原因与后来的使用模式和精神病风险之间的关系知之甚少。我们使用了来自多中心欧洲基因-环境相互作用（EU-GEI）病例对照研究的11个站点的数据。558名首发精神病患者（FEPp）和567名使用大麻并报告其RFUC的人群对照。我们运用逻辑回归来检验RFUC是否与首发精神病（FEP）病例对照状态相关。通径分析随后检查了RFUC、随后的大麻使用模式和病例对照状态之间的关系。对照组（86.1%）和FEPp（75.63%）最有可能报告“因为朋友”是他们最常见的RFUC。然而，20.1%的FEPp与5.8%的对照组相比，报告“感觉更好”作为他们的RFUC （χ2 = 50.97; p < 0.001）。“感觉更好”的RFUC与成为FEPp相关（OR 1.74; 95% CI 1.03-2.95），而“与朋友在一起”的RFUC与成为对照组相关（OR 0.56; 95% CI 0.37-0.83）。路径模型表明RFUC“感觉更好”与大量使用大麻和fepp控制状态之间存在关联。FEPp和对照组通常都是和他们的朋友一起开始使用大麻，但比对照组更多的病人开始使用“感觉更好”。那些声称第一次吸食大麻的原因是“感觉更好”的人比那些声称“因为朋友”的人更有可能过度使用大麻，并患上精神障碍。
While cannabis use is a well-established risk factor for psychosis, little is known about any association between reasons for first using cannabis (RFUC) and later patterns of use and risk of psychosis. We used data from 11 sites of the multicentre European Gene-Environment Interaction (EU-GEI) case–control study. 558 first-episode psychosis patients (FEPp) and 567 population controls who had used cannabis and reported their RFUC. We ran logistic regressions to examine whether RFUC were associated with first-episode psychosis (FEP) case–control status. Path analysis then examined the relationship between RFUC, subsequent patterns of cannabis use, and case–control status. Controls (86.1%) and FEPp (75.63%) were most likely to report ‘because of friends’ as their most common RFUC. However, 20.1% of FEPp compared to 5.8% of controls reported: ‘to feel better’ as their RFUC (χ2 = 50.97; p < 0.001). RFUC ‘to feel better’ was associated with being a FEPp (OR 1.74; 95% CI 1.03–2.95) while RFUC ‘with friends’ was associated with being a control (OR 0.56; 95% CI 0.37–0.83). The path model indicated an association between RFUC ‘to feel better’ with heavy cannabis use and with FEPp-control status. Both FEPp and controls usually started using cannabis with their friends, but more patients than controls had begun to use ‘to feel better’. People who reported their reason for first using cannabis to ‘feel better’ were more likely to progress to heavy use and develop a psychotic disorder than those reporting ‘because of friends’.