The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients
The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients
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DOI：
10.1186/1471-2369-15-159
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发表时间：
2014-10-01
期刊：
影响因子：
2.3
通讯作者：
Dede, Fatih
中科院分区：
文献类型：
--
作者：
Ates, Ihsan;Ozkayar, Nihal;Dede, Fatih
背景资料：本研究旨在检测高血压伴或不伴无症状器官损害（AOD）患者血清可溶性肿瘤坏死因子样弱凋亡诱导因子（sTWEAK）和白细胞介素17 A（IL-17 A）水平，并探讨其与颈动脉内膜中层厚度（CIMT）、蛋白尿、视网膜病变和左心室质量指数（LVMI）的关系。该研究包括159名诊断为原发性高血压（HT）并进行随访的患者;其中79名患者患有AOD（61名女性和18名男性），80名患者没有（52名女性和28名男性）。结果：COPD患者血清sTWEAK水平明显低于对照组（858.4pg/mL vs.1151.58pg/mL，P = 0.001）; sTWEAK水平与平均尿微量白蛋白水平和LVMI呈负相关。中位IL-17 A水平在有AOD的患者中显著高于无AOD的患者（2.34 pg/mL vs. 1.80 pg/mL，P = 0.001）。平均IL-17 A水平与平均尿微量白蛋白水平、CIMT和LVMI呈正相关。多变量逻辑回归分析显示，患者年龄、sTWEAK水平和平均24 h收缩压是AOD的预测因素。结论：AOD患者sTWEAK水平较低，IL-17 A水平较高。目前尚不清楚sTWEAK和IL-17 A是否在AOD的病理生理学中发挥作用。需要前瞻性观察性研究来确定sTWEAK和IL-17 A在靶器官损伤发展中的确切作用。
Background: This study aimed to measure the serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in hypertensive patients with/without asymptomatic organ damage (AOD), as well as to determine the relationship between the serum sTWEAK and IL17-A levels, and carotid intima media thickness (CIMT), proteinuria, retinopathy, and the left ventricle mass index (LVMI).Methods: The study included 159 patients diagnosed with and followed-up for primary hypertension (HT); 79 of the patients had AOD (61 female and 18 male) and 80 did not (52 female and 28 male). sTWEAK and IL-17A levels were measured in all patients.Results: The sTWEAK level was significantly lower in the patients with AOD than in those without AOD (858.4 pg/mL vs. 1151.58 pg/mL, P = 0.001). The sTWEAK level was negatively correlated with the mean microalbuminuria level and LVMI. The median IL-17A level was significantly higher in the patients with AOD than in those without AOD (2.34 pg/mL vs. 1.80 pg/mL, P = 0.001). There was a positive correlation between mean IL-17A level, and mean microalbuminuria level, CIMT, and LVMI. Multivariate logistic regression analysis showed that patient age, sTWEAK level, and mean 24-h systolic blood pressure were predictors of AOD.Conclusions: The sTWEAK level was lower and IL-17A level was higher in the patients with AOD. It remains unknown if sTWEAK and IL-17A play a role in the pathophysiology of AOD. Prospective observational studies are needed to determine the precise role of sTWEAK and IL-17A in the development of target organ damage.