Zebrafish airinemes optimize their shape between ballistic and diffusive search.
Zebrafish airinemes optimize their shape between ballistic and diffusive search.
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DOI：
10.7554/elife.75690
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发表时间：
2022-04-25
期刊：
影响因子：
7.7
通讯作者：
Sens, Pierre
中科院分区：
文献类型：
--
作者：
Park, Sohyeon;Kim, Hyunjoong;Wang, Yi;Eom, Dae Seok;Allard, Jun;Sens, Pierre
除了弥漫性信号外，组织中的细胞还通过细长的细胞突起进行交流，例如斑马鱼的气膜。在建立通讯之前，细胞突起必须找到它们的目标细胞。在这里，我们证明斑马鱼的航路形状与有限持久随机游动模型是一致的。在弹道搜索（直线）和扩散搜索（高度弯曲，随机）之间取得平衡，使接触目标细胞的概率最大化。我们发现，从活细胞显微镜中提取的斑马鱼的气道曲率与简单持久随机游走模型中的最优值大致相同。我们还探讨了目标单元推断航空业来源方向的能力，发现在搜索最优性和方向信息之间存在理论上的权衡。这提供了一个框架，以表征形状和性能目标，一般非典型细胞突起。
In addition to diffusive signals, cells in tissue also communicate via long, thin cellular protrusions, such as airinemes in zebrafish. Before establishing communication, cellular protrusions must find their target cell. Here, we demonstrate that the shapes of airinemes in zebrafish are consistent with a finite persistent random walk model. The probability of contacting the target cell is maximized for a balance between ballistic search (straight) and diffusive search (highly curved, random). We find that the curvature of airinemes in zebrafish, extracted from live-cell microscopy, is approximately the same value as the optimum in the simple persistent random walk model. We also explore the ability of the target cell to infer direction of the airineme’s source, finding that there is a theoretical trade-off between search optimality and directional information. This provides a framework to characterize the shape, and performance objectives, of non-canonical cellular protrusions in general.