Ultrasonic characterization of human cancellous bone in vitro using three different apparent backscatter parameters in the frequency range 0.6-15.0 MHz
Ultrasonic characterization of human cancellous bone in vitro using three different apparent backscatter parameters in the frequency range 0.6-15.0 MHz
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DOI：
10.1109/tuffc.2008.819
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发表时间：
2008-07-01
影响因子：
3.6
通讯作者：
Kaste, Sue C.
中科院分区：
文献类型：
--
作者：
Hoffmeister, Brent K.;Johnson, David P.;Kaste, Sue C.
基于明显反向散射测量的超声波技术可以为诊断骨质疏松症等骨疾病提供有用的手段。术语“表观”意味着反向散射信号没有针对衰减和衍射的频率相关效应进行补偿。我们对由 7 名捐赠者的左右股骨头制备的 23 块人类松质骨样本进行了体外表观反向散射测量。使用机械扫描系统从多个位置的每个样本获取反向散射信号。使用中心频率为 1、2.25、5、7.5 和 10 MHz 的五种不同的超声换能器进行扫描。这些传感器的 -6 dB 带宽覆盖了 0.6-15.0 MHz 的频率范围。分析反向散射信号以确定三个超声参数：表观积分反向散射 (AIB)、表观反向散射频率斜率 (FSAB) 和表观反向散射时间斜率 (TSAB)。使用线性回归分析来检查这些超声参数与标本的五个测量物理特征的相关性：质量密度、X射线骨矿物质密度、杨氏模量、屈服强度和极限强度。总共检查了 75 个此类相关性（3 个超声参数 X 5 个样本特征 X 5 个换能器）。使用 5 MHz (r = 0.70-0.89) 和 7.5 MHz (r = 0.75-0.93) 传感器观察到 AIB 具有良好的相关性；对于使用 2.25 MHz (r = 0.70-0.88)、5 MHz (T = 0.79-0.94) 和 7.5 MHz (r = 0.80-0.92) 传感器的 FSAB；对于 TSAB，使用 5 MHz (r = 0.68-0.89)、7.5 MHz (r = 0.75-0.89) 和 10 MHz (r = 0.75-0.92) 传感器。
Ultrasonic techniques based on measurements of apparent backscatter may provide a useful means for diagnosing bone diseases such as osteoporosis. The term "apparent" means that the backscattered signals are not compensated for the frequency-dependent effects of attenuation and diffraction. We performed in vitro apparent backscatter measurements on 23 specimens of human cancellous bone prepared from the left and right femoral heads of seven donors. A mechanical scanning system was used to obtain backscattered signals from each specimen at several sites. Scans were performed using five different ultrasonic transducers with center frequencies of 1, 2.25, 5, 7.5, and 10 MHz. The -6 dB bandwidths of these transducers covered a frequency range of 0.6-15.0 MHz. The backscattered signals were analyzed to determine three ultrasonic parameters: apparent integrated backscatter (AIB), frequency slope of apparent backscatter (FSAB), and time slope of apparent backscatter (TSAB). Linear regression analysis was used to examine the correlation of these ultrasonic parameters with five measured physical characteristics of the specimens: mass density, x-ray bone mineral density, Young's modulus, yield strength, and ultimate strength. A total of 75 such correlations were examined (3 ultrasonic parameters X 5 specimen characteristics X 5 transducers). Good correlations were observed for AIB using the 5 MHz (r = 0.70-0.89) and 7.5 MHz (r = 0.75-0.93) transducers; for FSAB using the 2.25 MHz (r = 0.70-0.88), 5 MHz (T = 0.79-0.94), and 7.5 MHz (r = 0.80-0.92) transducers; and for TSAB using the 5 MHz (r = 0.68-0.89), 7.5 MHz (r = 0.75-0.89), and 10 MHz (r = 0.75-0.92) transducers.