Characterization of Inflammation and Fibrosis in Crohn's Disease Lesions by Magnetic Resonance Imaging
Characterization of Inflammation and Fibrosis in Crohn's Disease Lesions by Magnetic Resonance Imaging
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DOI：
10.1038/ajg.2014.424
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发表时间：
2015-03-01
影响因子：
9.8
通讯作者：
Cuatrecasas, Miriam
中科院分区：
文献类型：
--
作者：
Rimola, Jordi;Planell, Nuria;Cuatrecasas, Miriam
结论：克罗恩病（CD）纤维化成分的测量可能具有重要的治疗意义。本研究的目的是表征的磁共振成像（MRI）的结果是差异相关的存在纤维化和炎症活动相关的，使用手术切除的肠道病变的病理分析作为参考standard.METHODS：MRI研究与相同的成像协议的41 CD患者进行了择期肠切除术前4个月内进行了审查。MRI评价了钆注射后70 s和7 min时的壁增厚、水肿、溃疡、粘膜下层信号强度、狭窄和动态研究各阶段的增强模式以及该模式随时间的变化。病理炎症和纤维化评分分为三个严重程度。结果：在所有41例患者的44个节段进行了分析。炎症的病理强度与以下MRI参数相关：T2高信号（P=0.02）、粘膜增强（P=0.03）、溃疡（P=0.01）和边缘模糊（P=0.05）。纤维化程度与增强增益百分比相关（P
OBJECTIVES: Measurement of the component of fibrosis in Crohn's disease (CD) may have important therapeutic implications. The aim of this study was to characterize the Magnetic Resonance Imaging (MRI) findings that are differentially associated with the presence of fibrosis and those associated with inflammatory activity, using the pathological analysis of surgically resected intestinal lesions as reference standard.METHODS: MRI studies with identical imaging protocol of 41 CD patients who underwent elective bowel resection within 4 months before surgery were reviewed. MRI evaluated wall thickening, edema, ulcers, signal intensity at submucosa at 70 s and 7 min after gadolinium injection, stenosis, and pattern of enhancement in each phase of the dynamic study and changes on this pattern over time. Pathological inflammatory and fibrosis scores were classified into three grades of severity.RESULTS: In all, 44 segments from 41 patients were analyzed. The pathological intensity of inflammation was associated with the following MRI parameters: hypersignal on T2 (P=0.02), mucosal enhancement (P=0.03), ulcerations (P=0.01), and blurred margins (P=0.05). The degree of fibrosis correlated with the percentage of enhancement gain (P