The radiobiological principles of boron neutron capture therapy: A critical review
The radiobiological principles of boron neutron capture therapy: A critical review
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DOI：
10.1016/j.apradiso.2011.04.019
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发表时间：
2011-12-01
影响因子：
1.6
通讯作者：
Coderre, J. A.
中科院分区：
文献类型：
--
作者：
Hopewell, J. W.;Morris, G. M.;Coderre, J. A.
检查BNCT暴露中剂量组分的放射生物学。由于亚致死性损伤的修复，在确定伽马射线的生物学有效性中的暴露时间的影响在BNCT的应用中在很大程度上被忽视了。来自快中子的反冲质子在其相对生物学有效性（RBE）方面作为能量和组织终点的函数而变化。因此，射束的能谱将影响该剂量分量的RBE。来自氮中的中子俘获反应的质子尚未被研究，但在实践中，来自氮俘获的质子已与反冲质子贡献结合成总质子剂量。中子俘获反应产物在硼中的相对生物有效性来自两个因素，短程粒子的RBE和硼的生物分布，统称为复合生物有效性因子。在将这些因子应用于不同的正常组织和肿瘤时需要谨慎。(C)2011爱思唯尔有限公司版权所有。
The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of gamma-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors. (C) 2011 Elsevier Ltd. All rights reserved.