Prevalence of Mild Cognitive Impairment by Multiple Classifications: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Project
Prevalence of Mild Cognitive Impairment by Multiple Classifications: The Monongahela-Youghiogheny Healthy Aging Team (MYHAT) Project
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DOI：
10.1097/jgp.0b013e3181cdee4f
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发表时间：
2010-08-01
影响因子：
7.2
通讯作者：
Lee, Ching-Wen
中科院分区：
文献类型：
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作者：
Ganguli, Mary;Chang, Chung-Chou H.;Lee, Ching-Wen
目的：用不同的分类方法估计和比较轻度认知障碍（MCI）和相关实体在人群水平上的频率和患病率。设计：以人口为基础的横断面流行病学研究，通过年龄分层随机抽样从选民名册中招募。背景：宾夕法尼亚州西部的小镇社区。参与者：在2036名65岁及以上的个体中，1982名参与者认知正常或轻度受损（年龄教育校正的迷你精神状态得分>= 21）。测量方法：人口统计学、以认知领域、功能能力表达的神经心理学评估和认知困难的主观报告；基于这些测量，有临床痴呆评分（CDR）量表的操作标准、1999年失忆性轻度认知损伤标准、2004年扩充型轻度认知损伤标准和新的纯认知型轻度认知损伤标准。结果：27.6%的参与者的CDR评分为0.5（不确定/非常轻度痴呆），而1.2%的参与者的CDR >= 1（轻度或中度痴呆）。在那些有CDR的人中
Objectives: To estimate and compare the frequency and prevalence of mild cognitive impairment (MCI) and related entities using different classification approaches at the population level. Design: Cross-sectional epidemiologic study of population-based cohort recruited by age-stratified random sampling from electoral rolls. Setting: Small-town communities in western Pennsylvania. Participants: Of 2,036 individuals aged 65 years and older, 1,982 participants with normal or mildly impaired cognition (age-education-corrected Mini-Mental State scores >= 21). Measurements: Demographics, neuropsychological assessment expressed as cognitive domains, functional ability, and subjective reports of cognitive difficulties; based on these measurements, operational criteria for the Clinical Dementia Rating (CDR) scale, the 1999 criteria for amnestic MCI, the 2004 Expanded criteria for MCI, and new, purely cognitive criteria for MCI. Results: A CDR rating of 0.5 (uncertain/very mild dementia) was obtained by 27.6% of participants, whereas 1.2% had CDR >= 1 ( mild or moderate dementia). Among those with CDR