Drug abstinence and cognitive control in methamphetamine-dependent individuals.
Drug abstinence and cognitive control in methamphetamine-dependent individuals.
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DOI：
10.1016/j.jsat.2009.03.004
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发表时间：
2009-10
影响因子：
3.9
通讯作者：
Leamon MH
中科院分区：
文献类型：
--
作者：
Salo R;Nordahl TE;Galloway GP;Moore CD;Waters C;Leamon MH
长期滥用甲基苯丙胺(MA)与额纹状体功能中断以及认知控制缺陷有关。为了检验药物使用模式和认知缺陷之间的关系，我们将以前发表的行为数据与使用Stroop注意力测试收集的新数据合并在一起。研究对象组包括38名近期开始戒毒的MA滥用者[36.1±8.8岁]、27名在研究前一年开始戒毒的MA滥用者[38.7±7.7岁]和33名非物质滥用对照组[33.9±8.5岁]。与对照组[p=.001]和长期戒毒者[p=.01]相比，近期戒毒的MA滥用者表现出更大的Stroop反应时(RT)干扰。在长期禁欲MA滥用者和对照组之间没有发现差异[p=.87]。Stroop RT干扰与药物使用时间[p=.003]和戒毒时间[p=.05]均呈正相关。目前研究中的数据提供了证据，表明长期戒毒可能会改善认知功能。
Chronic methamphetamine (MA) abuse is associated with disruption of frontostriatal function as well as deficits in cognitive control. In order to examine the relationship between drug use patterns and cognitive deficits we pooled previously published behavioral data with new data collected using the Stroop Attention Test. Subject groups comprised 38 MA abusers who recently initiated abstinence [36.1 ± 8.8 yrs of age], 27 MA abusers who had initiated abstinence > one year prior to study [38.7 ± 7.7 yrs of age) and 33 non-substance abusing controls [33.9 ± 8.5 yrs of age]. The recently abstinent MA abusers exhibited greater Stroop reaction time (RT) interference compared to both the control group [p= .001] and the Long-term abstinent MA abusers [p=.01]. No difference was seen between long-term abstinent MA abusers and controls [p=.87]. Stroop RT interference correlated positively with both duration of drug use [p =.003] and drug abstinence [p= .05]. The data in the current study provide evidence that cognitive function may improve with protracted drug abstinence.