Pd-catalyzed asymmetric hydrogenation of α-fluorinated iminoesters in fluorinated alcohol:: A new and catalytic enantioselective synthesis of fluoro α-amino acid derivatives
Pd-catalyzed asymmetric hydrogenation of α-fluorinated iminoesters in fluorinated alcohol:: A new and catalytic enantioselective synthesis of fluoro α-amino acid derivatives
复制标题
DOI：
10.1021/ol0002471
复制
发表时间：
2001-02-08
期刊：
影响因子：
5.2
通讯作者：
Uneyama, K
中科院分区：
文献类型：
--
作者：
Abe, H;Amii, H;Uneyama, K
在氢气压力下，催化量的三氟乙酸钯（II）和2，2 ′-双（二苯基膦基）-1，1 ′-联萘（BINAP）促进α-氟化亚氨基酯的不对称氢化，得到高度对映体富集的β-氟化α-氨基酯。采用含氟醇如2，2，2-三氟乙醇可使收率和ee值提高到91%以上。
[GRAPHICS]Under hydrogen pressure, a catalytic amount of palladium(II) trifluoroacetate and 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) promoted asymmetric hydrogenation of alpha -fluorinated iminoesters to afford highly enantioenriched beta -fluorinated alpha -amino esters. The yield and ee were much improved by employing fluorinated alcohols such as 2,2,2-trifluoroethanol (up to 91% eel.