Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs.
Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs.
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甲苯二异氰酸酯诱导豚鼠气道高反应性和炎症。
DOI：
10.1164/arrd.1985.132.5.1106
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Scypinski,L
中科院分区：
文献类型：
--
作者：
Gordon,T;Sheppard,D;McDonald,DM;Distefano,S;Scypinski,L
We examined the changes in airway responsiveness to increasing doses of an acetylcholine aerosol in anesthetized and ventilated guinea pigs 2, 6, or 24 h after exposure to 2 ppm toluene diisocyanate (TDI) or 2 h after exposure to air or 1 ppm TDI. Pulmonary resistance (Rl) after the animals inhaled a buffered saline aerosol was used as baseline and was similar for air and TDI groups. The concentration of acetylcholine calculated to cause a 200% increase in Rlwas significantly lower for animals studied at 2 h (0.68%) or at 6 h (0.77%), but not at 24 h (2.39%), after TDI than for air animals (3.07%). The increase in airway responsiveness in the TDI-exposed animals was associated with histologic changes in the trachea and intrapulmonary airways. Exposure to 2 ppm TDI caused a patchy loss of cilia, shedding of epithelial cells into the airway lumen, and an influx of inflammatory cells into the trachea and other airways. In the lamina propria of the trachea, the concentration of extravascular polymorphonuclear leukocytes (PMN) was 13- to 26-fold greater in animals studied 2 or 6 h after exposure to 2 ppm TDI or at 2 h after 1 ppm TDI than in animals exposed to air. The concentration of PMN in the epithelium was significantly increased only in animals examined 2 h after 2 ppm TDI. Exposure to TDI also caused an influx of eosinophils into the tracheal mucosa. This influx occurred later and was more persistent than the influx of PMN. These results indicate that a single exposure to TDI can cause an increase in airway responsiveness that is associated with epithelial injury and acute airway inflammation.
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豚鼠的组胺剂量反应曲线。
影响因子：
3.3
作者：
W. Hulbert;T. McLean;B. Wiggs;P. Paré;J. Hogg
通讯作者：
J. Hogg
气道炎症对于臭氧引起的高反应性的重要性。
DOI：
10.1164/arrd.1983.127.6.686
发表时间：
1983
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Holtzman,MJ;Fabbri,LM;O'Byrne,PM;Gold,BD;Aizawa,H;Walters,EH;Alpert,SE;Nadel,JA
通讯作者：
Nadel,JA
CO2 和 pH 对血清素与乙酰胆碱引起的支气管收缩的影响。
影响因子：
3.3
作者：
G. Sterling;P. Holst;J. Nadel
通讯作者：
J. Nadel
臭氧对豚鼠对组胺呼吸反应的影响。
DOI：
10.1080/15287398009529841
发表时间：
1980
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
T. Gordon;M. O. Amdur
通讯作者：
M. O. Amdur
臭氧引起的支气管高反应期间豚鼠气道粘膜病理变化的序列。
DOI：
10.1164/arrd.1985.131.3.314
发表时间：
1985
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Murlas,CG;Roum,JH
通讯作者：
Roum,JH