Development of Candida-associated denture stomatitis: new insights
Development of Candida-associated denture stomatitis: new insights
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DOI：
10.1590/s1678-77572008000200002
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发表时间：
2008-04-01
影响因子：
2.7
通讯作者：
Ten Cate, Jacob Martien
中科院分区：
文献类型：
--
作者：
Pereira-Cenci, Tatiana;Del Bel Cury, Altair Antoninha;Ten Cate, Jacob Martien
尽管治疗进展，机会性口腔真菌感染性疾病的患病率增加，特别是在义齿佩戴者。酵母细胞在义齿基托和义齿换衬材料中的不规则处截留、口腔卫生不良和几种全身因素的组合是这种感染性疾病发作的最可能原因。因此，假丝酵母菌在假体上的定植和生长具有临床重要性。本文就影响义齿相关性口腔炎念珠菌粘附的几个关键因素进行综述。虽然在表面性质的作用上存在一些共识，但对其他几个因素的研究，如义齿衬垫的使用、唾液性质和酵母菌-细菌相互作用，显示出相互矛盾的结果。由于实验方案的巨大变化，相互矛盾的发现阻碍了全面的基本理解，而其他因素从未被彻底研究过。表面自由能和表面粗糙度控制的初始粘附，但时间的变化还没有报道。也没有在体内研究表明，如果基层类型是决定生物膜的积累在口腔环境中较长的时间是至关重要的。由于唾液收集和处理的差异等因素，唾液的贡献尚不清楚。初步研究结果表明，细菌对于念珠菌在生物膜中的成功建立也是至关重要的，但这一观察结果的临床意义尚未得到证实。总之，有必要标准化实验程序，弥合实验室和体内方法和结果之间的差距，并在一般情况下，彻底调查的因素，调节初始附着和随后的殖民义齿基托材料和口腔粘膜的念珠菌感染的患者。需要关于如何控制这些因素的信息，这可能有助于预防疾病。鉴于念珠菌病问题在全世界范围内的严重性，这些信息的社会影响是重大的。
Despite therapeutic progress, opportunistic oral fungal infectious diseases have increased in prevalence, especially in denture wearers. The combination of entrapment of yeast cells in irregularities in denture-base and denture-relining materials, poor oral hygiene and several systemic factors is the most probable cause for the onset of this infectious disease. Hence colonization and growth on prostheses by Candida species are of clinical importance. The purpose of this review is to critically discuss several key factors controlling the adhesion of Candida species which are relevant to denture-associated stomatitis. Although there is some consensus on the role of surface properties, studies on several other factors, as the use of denture liners, salivary properties and yeast-bacterial interactions, have shown contradictory findings. A comprehensive fundamental understanding is hampered by conflicting findings due to the large variations in experimental protocols, while other factors have never been thoroughly studied. Surface free energy and surface roughness control the initial adherence, but temporal changes have not been reported. Neither have in vivo studies shown if the substratum type is critical in dictating biofilm accumulation during longer periods in the oral environment. The contribution of saliva is unclear due to factors like variations in its collection and handling. Initial findings have disclosed that also bacteria are crucial for the successful establishment of Candida in biofilms, but the clinical significance of this observation is yet to be confirmed. In conclusion, there is a need to standardize experimental procedures, to bridge the gap between laboratory and in vivo methodologies and findings and - in general - to thoroughly investigate the factors that modulate the initial attachment and subsequent colonization of denture-base materials and the oral mucosa of patients subjected to Candida infections. Information on how these factors can be controlled is required and this may help to prevent the disease. The societal impact of such information is significant given the magnitude of the candidosis problem worldwide.