Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats.
Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats.
复制标题
配对饲养不会改变雌性和雄性大鼠自我服用海洛因后的渴望、消退和恢复的潜伏期。
DOI：
10.1037/bne0000544
复制
发表时间：
2023
影响因子：
1.9
通讯作者：
LaLumiere,RyanT
中科院分区：
文献类型：
--
作者：
Nett,KelleE;LaLumiere,RyanT
有证据表明，在大鼠中的单一住房作为一种慢性应激源，提高了它有助于海洛因渴望的措施和对住房改善这些措施的可能性。本研究的目的是确定是否对住房后，海洛因自我管理减少孵化的渴望，灭绝，并恢复海洛因寻求。单独圈养的雌性和雄性Sprague-Dawley大鼠每天进行6小时海洛因自我给药，其中主动杠杆按压产生与光/音调提示配对的海洛因输注。自我给药后一天，大鼠接受基线线索寻找测试，其中主动按压杠杆仅产生光/音调线索。在该线索寻求试验后，立即将大鼠与体重和性别匹配的未处理大鼠成对饲养，或在研究的剩余时间内保持单独饲养。在14天里，大鼠留在自己的家中，之后他们接受了一个线索寻求测试，以评估与基线测试相比的渴望孵化。然后，大鼠进行灭绝会议，然后由线索诱导和海洛因引发的恢复。研究结果表明，对圈养大鼠没有不同的单圈养大鼠在孵化的渴望，灭绝，或恢复海洛因寻求。此外，研究结果没有显示任何基于性别差异的证据。目前的工作表明，对住房在强制禁欲期间不改变措施的海洛因渴望/寻求。这些研究结果表明，特别是在强迫禁欲期间，单一住房的长期压力并不有助于这种措施的程度。（PsycInfo数据库记录（c）2023阿帕，保留所有权利）
Evidence suggests that single housing in rats acts as a chronic stressor, raising the possibilities that it contributes to measures of heroin craving and that pair housing ameliorates such measures. This study aimed to determine whether pair housing after heroin self-administration reduces the incubation of craving, extinction, and reinstatement of heroin seeking. Single-housed female and male Sprague-Dawley rats underwent daily 6-hr heroin self-administration, wherein active lever presses produced a heroin infusion paired with light/tone cues. One day after self-administration, rats underwent a baseline cued-seeking test wherein active lever presses only produced light/tone cues. Immediately following this cued-seeking test, rats were either pair-housed with weight-and sex-matched naïve rat or remained single-housed for the rest of the study. For 14 days, rats remained in their homecages, after which they underwent a cued-seeking test to assess the incubation of craving compared to their baseline test. Rats then underwent extinction sessions followed by cue-induced and heroin-primed reinstatements. The findings reveal that pair-housed rats did not differ from single-housed rats in terms of the incubation of craving, extinction, or reinstatement of heroin seeking. Additionally, the results did not reveal any evidence of sex-based differences in the study. The present work indicates that pair housing during the forced abstinence period does not alter measures of heroin craving/seeking. These findings suggest that the chronic stress of single housing specifically during forced abstinence does not contribute to the degree of such measures.(PsycInfo Database Record (c) 2023 APA, all rights reserved)