Relationship of medical status, medications, and salivary flow rates in adults of different ages
Relationship of medical status, medications, and salivary flow rates in adults of different ages
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DOI：
10.1016/s1079-2104(96)80410-0
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Pogoda, JM
中科院分区：
文献类型：
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作者：
Navazesh, M;Brightman, VJ;Pogoda, JM
据报道，多种全身性疾病和药物会导致口干症或唾液腺功能减退。本研究的目的是评估全身性疾病、药物和唾液流速之间的关系。随机选择了 63 名年龄在 23 岁至 82 岁之间的门诊牙科患者。记录全身性疾病和药物的性质、持续时间和数量。重复测量未刺激的整体、咀嚼刺激的整体、酸刺激的腮腺和糖果刺激的腮腺唾液流速。使用 Wilcoxon 秩和检验、非参数多元方差分析和 Fisher 精确检验对数据进行分析。对于正在服用药物的全身性疾病患者，所有唾液流速均显着 (p = 0.03 - 0.001) 低于健康人的流速。在患有至少一种全身性疾病的正在服药的患者中，服药时间超过 2 年的患者的未刺激全唾液 (p = 0.002)、咀嚼刺激全唾液 (p = 0.0004) 和糖果刺激腮腺唾液 (p = 0.02) 流速显着低于已服药 1 至 2 年的患者。全身性疾病的数量显着（p = 0.02）并对酸刺激的腮腺唾液率产生负面影响。根据未刺激的全唾液和酸刺激的腮腺唾液确定的唾液功能减退的患病率显着较高（p =
Multiple systemic disorders and medications have been reported to cause xerostomia or salivary gland hypofunction. The purpose of this study was to evaluate the relationship among systemic disorders, medications, and salivary flow rates. Sixty-three ambulatory dental patients aged 23 to 82 years were randomly selected. The nature, duration, and number of systemic disorders and medications were documented. Repeated measurements of unstimulated whole, chewing-stimulated whole, acid-stimulated parotid, and candy-stimulated parotid salivary flow rates were obtained. Data were analyzed with the Wilcoxon rank-sum test, nonparametric multivariate analysis of variance, and Fisher's exact test. For persons with systemic disorders who were taking medication, all salivary flow rates were significantly (p = 0.03 - 0.001) lower than the flow rates in healthy persons. Among persons with at least one systemic disorder who were taking medication, those who had been taking medication for longer than 2 years had significantly lower unstimulated whole saliva (p = 0.002), chewing-stimulated whole saliva (p = 0.0004), and candy-stimulated parotid saliva (p = 0.02) flow rates than those who had been taking medication for 1 to 2 years. The number of systemic disorders significantly (p = 0.02) and negatively affected the acid-stimulated parotid salivary rates. The prevalence of salivary hypofunction determined on the basis of unstimulated whole saliva and acid-stimulated parotid saliva was significantly higher (p =