Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach
Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach
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DOI：
10.1111/j.1468-1331.2008.02092.x
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发表时间：
2008-04-01
影响因子：
5.1
通讯作者：
Combarros, O.
中科院分区：
文献类型：
--
作者：
Infante, J.;Garcia-Gorostiaga, I.;Combarros, O.
在来自西班牙的197名PD患者和173名对照受试者组成的明确组中，通过集合关联方法的多位点方法首次应用于分析参与帕金森病（PD）脑神经炎症通路的五个基因簇[肿瘤坏死因子α（TNF-alpha）、白细胞介素6（IL-6）、IL-8、IL-1 α和IL-10]。集关联分析没有显示这些炎症基因对PD风险的独立或交互作用。
For the first time, the multilocus approach by the set-association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8, IL-1 alpha and IL-10] involved in the brain neuroinflammatory pathway in Parkinson's disease (PD), in a well-defined group of 197 PD patients and 173 control subjects from Spain. Set-association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.