Bacterial cell membranes and their role in daptomycin resistance: A review.
Bacterial cell membranes and their role in daptomycin resistance: A review.
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DOI：
10.3389/fmolb.2022.1035574
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发表时间：
2022
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
脂质在细菌细胞中发挥着重要作用。首先，脂质是细胞膜双层的主要成分，提供结构并将细胞与周围环境分开。这使得脂质双层成为抗菌肽和达托霉素等膜作用抗生素的主要靶标。作为回应，细菌进化出机制，使膜能够适应这些抗菌化合物的攻击。在这篇综述中，我们重点关注肠球菌、金黄色葡萄球菌和草绿色链球菌中与达托霉素耐药相关的膜磷脂变化。
Lipids play a major role in bacterial cells. Foremost, lipids are the primary constituents of the cell membrane bilayer, providing structure and separating the cell from the surrounding environment. This makes the lipid bilayer a prime target for antimicrobial peptides and membrane-acting antibiotics such as daptomycin. In response, bacteria have evolved mechanisms by which the membrane can be adapted to resist attack by these antimicrobial compounds. In this review, we focus on the membrane phospholipid changes associated with daptomycin resistance in enterococci, Staphylococcus aureus, and the Viridans group streptococci.
影响因子：
3.3
作者：
Rahman M;Nguyen SV;McCullor KA;King CJ;Jorgensen JH;McShan WM
通讯作者：
McShan WM