Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: A controlled, double dissociation study
Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: A controlled, double dissociation study
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DOI：
10.1016/s0006-3223(02)01814-0
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发表时间：
2003-08-15
影响因子：
10.6
通讯作者：
Bellodi, L
中科院分区：
文献类型：
--
作者：
Cavallaro, R;Cavedini, P;Bellodi, L
背景：多项研究表明，强迫症(OCD)和精神分裂症(SKZ)患者的前额叶皮质功能障碍与两个部分独立的神经解剖系统有关：腹内侧额叶皮质和背外侧前额叶皮质，它们具有不同的神经解剖联系，包括纹状体。本研究的主要目的是使用双分离研究(神经心理任务中的背外侧前额叶皮质和腹内侧额前皮质)来验证这一假说。方法：我们对110名强迫症患者、67名强迫症患者和56名对照受试者进行了威斯康星卡片分类测验、赌博任务和四盘版的河内塔测验。结果：威斯康星卡片分类测验和赌博任务表现存在明显的双分离，其中SKZ患者在威斯康星卡片分类测验中的表现显著差于强迫症患者和对照组以及强迫症患者。SKZ和强迫症患者的河内塔功能均明显低于对照组。结论：我们的双分离研究结果证实了SKZ和强迫症患者不同额叶亚系参与基底-皮质-额叶回路功能的假说。(C)2003年生物精神病学学会。
Background: Several lines of research suggest that prefrontal cortex dysfunctions observed in obsessive compulsive disorder (OCD) and schizophrenia (SKZ) are linked to two partially independent neuroanatomic systems: the ventromedial prefrontal cortex and the dorsolateral prefrontal cortex, with different neuroanatomic connections, including the striatum. The primary aim of this study was to test this hypothesis using a double dissociation study (of neuropsychological tasks performance of the dorsolateral prefrontal cortex and ventromedial prefrontal cortex.Methods: We administered the Wisconsin Card Sorting Test, the Gambling Task, and the four-disk version of the Tower of Hanoi to 110 SKZ and 67 OCD patients and 56 control subjects.Results: A clear double dissociation of Wisconsin Card Sorting Test and Gambling Task performances was found, with SKZ patients performing the Wisconsin Card Sorting test significantly worse than OCD patients and control subjects and OCD patients performing the Gambling Task significantly worse than SKZ and control subjects. Both SKZ and OCD patients performed the Tower of Hanoi significantly worse than control subjects.Conclusions: Results from our double dissociation study confirm the hypothesis of involvement of different frontal lobe subsystems within basal-corticofrontal circuits function in SKZ and OCD. (C) 2003 Society of Biological Psychiatry.