Influenza-associated deaths in tropical Singapore.
Influenza-associated deaths in tropical Singapore.
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DOI：
10.3201/eid1201.050826
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发表时间：
2006-01
影响因子：
11.8
通讯作者：
Chew SK
中科院分区：
文献类型：
--
作者：
Chow A;Ma S;Ling AE;Chew SK
需要对热带国家的高危人群进行监测和每年接种疫苗。我们使用回归模型来检验1996-2003年期间流感对新加坡热带地区死亡率的影响。甲型流感（H3N2）是主要的流行流感病毒亚型，对死亡率的影响一贯显著而强劲。流感与各种原因、潜在肺炎和流感以及潜在循环系统和呼吸系统疾病的年死亡率相关，分别为每10万人年14.8（95%可信区间9.8-19.8）、2.9（1.0-5.0）和11.9（8.3-15.7）。这些结果与美国和亚热带香港的观测结果相当。估计有6.5%的潜在肺炎和流感死亡可归因于流感。50至65岁人群中与流感相关的死亡比例是一般人群的11.3倍。我们的研究结果支持对热带国家高危人群进行流感监测和每年接种流感疫苗的必要性。
Surveillance and annual vaccination are needed for at-risk populations in tropical countries. We used a regression model to examine the impact of influenza on death rates in tropical Singapore for the period 1996–2003. Influenza A (H3N2) was the predominant circulating influenza virus subtype, with consistently significant and robust effect on mortality rates. Influenza was associated with an annual death rate from all causes, from underlying pneumonia and influenza, and from underlying circulatory and respiratory conditions of 14.8 (95% confidence interval 9.8–19.8), 2.9 (1.0–5.0), and 11.9 (8.3–15.7) per 100,000 person-years, respectively. These results are comparable with observations in the United States and subtropical Hong Kong. An estimated 6.5% of underlying pneumonia and influenza deaths were attributable to influenza. The proportion of influenza-associated deaths was 11.3 times higher in persons age >65 years than in the general population. Our findings support the need for influenza surveillance and annual influenza vaccination for at-risk populations in tropical countries.