Topographic organization of projection from the parabigeminal nucleus to the superior colliculus in the ferret revealed with fluorescent latex microspheres
Topographic organization of projection from the parabigeminal nucleus to the superior colliculus in the ferret revealed with fluorescent latex microspheres
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DOI：
10.1016/s0006-8993(96)01042-6
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发表时间：
1996-12-16
期刊：
影响因子：
2.9
通讯作者：
Moore, DR
中科院分区：
文献类型：
--
作者：
Jiang, ZD;King, AJ;Moore, DR
将红色和绿色荧光乳胶微球或与辣根过氧化物酶结合的麦胚凝集素（WGA-HRP）单侧离散注射到雪貂的上级丘（SC）中，以表征从二叠旁核（PEN）投射的地形组织。逆行标记的PEN显示，这个核项目双边的SC，虽然最重的投影来自同侧PEN。PEN-SC的投影展示了一个高度有序的组织沿着喙尾轴;喙PEN项目喙SC和尾PEN项目尾SC。尾腹侧和rostrodoral地区的PEN项目主要是同侧和对侧SC，分别。同侧投射主要终止于SC的尾侧区，而对侧投射主要终止于SC的吻侧区。同侧投射到SC外侧的神经元主要位于PEN的腹侧区，而投射到SC外侧的神经元主要位于核的背侧区，对侧PEN主要投射到SC的头外侧象限。这些结果表明SC的每个象限主要受PEN的限制部分支配：接受最重同侧输入的尾外侧象限和尾内侧象限分别主要由同侧PEN的腹侧和背侧部分靶向;接受最弱输入的头外侧象限由对侧PEN靶向，而接受最弱输入的头内侧象限由两侧核的背侧部分靶向。这些研究结果表明，在PEN的活动被中继到SC的不同区域的形式，一个高度有序的地形投影。邻近的外侧被盖（ALT）也严重突出到SC，主要是在同侧。ALT投射到同侧SC的组织似乎不那么有序，主要终止于尾侧SC，尤其是尾外侧象限。对侧投影无明显地形图。
Unilateral, discrete injections of red and green fluorescent latex microspheres or injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) were made into the ferret's superior colliculus (SC) to characterize the topographic organization of the projection from the parabigeminal nucleus (PEN). Retrograde labelling in the PEN revealed that this nucleus projects bilaterally to the SC, although the heaviest projection arises from the ipsilateral PEN. The PEN-SC projection demonstrates a highly ordered organization along the rostral-caudal axis; rostral PEN projects to rostral SC and caudal PEN projects to caudal SC. The caudoventral and rostrodorsal areas of the PEN project mainly to the ipsilateral and contralateral SC, respectively. The ipsilateral pathway terminates principally in the caudal region of the SC, while the contralateral projection terminates predominantly in rostral SC. Ipsilaterally, there are slightly more neurons, located mainly in the ventral PEN, that project to the lateral SC than those, located largely in the dorsal part of the nucleus, that target the medial SC. The contralateral PEN mainly projects to the rostrolateral quadrant of the SC. These results indicate that each quadrant of the SC is innervated principally by a restricted part of the PEN: the caudolateral quadrant, which receives the heaviest ipsilateral input, and the caudomedial quadrant are targeted predominantly by the ventral and dorsal portions, respectively, of the ipsilateral PEN; the rostrolateral quadrant by the contralateral PEN, and the rostromedial quadrant, which receives the weakest input, by the dorsal portion of the nucleus on both sides. These findings suggest that activity in the PEN is relayed to distinct regions of the SC in the form of a highly ordered topographic projection. The adjacent lateral tegmentum (ALT) also projects heavily to the SC, principally on the ipsilateral side. The ALT projection to the ipsilateral SC appears to be organized in a less orderly fashion, and terminates principally in caudal SC, particularly the caudolateral quadrant. No topography was apparent for the contralateral projection.