Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients
Corpus callosum morphology in first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study of Chinese Singaporean patients
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DOI：
10.1192/bjp.bp.113.127886
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发表时间：
2014-01-01
影响因子：
10.5
通讯作者：
Sim, Kang
中科院分区：
文献类型：
--
作者：
Collinson, Simon L.;Gan, Swu Chyi;Sim, Kang
背景 精神分裂症患者胼胝体异常的报道已有30多年的历史，但个体差异和疾病特征的影响仍有待充分阐明。目的 探讨个体和疾病特征对新加坡华裔精神分裂症患者胼胝体的影响。方法采用磁共振和弥散张量成像技术，测量胼胝体平均面积、体积和分数 研究人员对 120 名新加坡华人患者（52 名慢性精神分裂症患者和 68 名首发精神分裂症患者）进行了各向异性研究，并与 75 名匹配的健康对照者的数据进行了比较。结果 患者的胼胝体面积和体积均较对照者显着减小，但患者和对照者的性别之间胼胝体不存在显着差异。相对于首次发作的患者和对照组，慢性病患者的胼胝体面积和体积差异最大。无论病情如何，患者的胼胝体前部与对照组没有什么不同。结论随着疾病的进展，胼胝体的形态异常可能会增加。
Background Abnormalities in the corpus callosum have been reported in patients with schizophrenia for over 30 years but the influence of inter-individual differences and illness characteristics remains to be fully elucidated.Aims To examine the influence of individual and illness characteristics on the corpus callosum in Chinese Singaporean patients with schizophrenia.Method Using magnetic resonance and diffusion tensor imaging, mean corpus callosum area, volume and fractional anisotropy were investigated in 120 Chinese Singaporean patients (52 with chronic and 68 with first-episode schizophrenia) and compared with data from 75 matched healthy controls.Results Both area and volume were significantly reduced in patients relative to controls but no significant differences in corpus callosum existed between genders in either patients or controls. Differences in area and volume of the corpus callosum were greatest in patients whose condition was chronic relative to patients with a first episode and controls. Anterior callosum in patients, regardless of chronicity, was no different to that of controls.Conclusions Morphological abnormalities in the corpus callosum may increase with illness progression.