High frequency oscillations and seizure frequency in patients with focal epilepsy
High frequency oscillations and seizure frequency in patients with focal epilepsy
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DOI：
10.1016/j.eplepsyres.2009.03.026
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发表时间：
2009-08-01
影响因子：
2.2
通讯作者：
Gotman, Jean
中科院分区：
文献类型：
--
作者：
Zijlmans, Maeike;Jacobs, Julia;Gotman, Jean
高频振荡（hfo）与致痫性有关。在大鼠中，HFOs的程度（bb0 ~ 200hz）与癫痫发作频率相关。我们研究了局灶性癫痫患者是否也有同样的情况。对39例2000 Hz脑电采样的患者进行了间期纹波（80 ~ 250 Hz）、快速纹波（250 ~ 500 Hz）和尖峰波的研究。植入前癫痫发作频率与HFOs通道数（>.1 /min）进行比较。重复分析bbbb5、b>0和b>0的HFO率。单独分析了25例颞叶癫痫患者和12例选择相似的单侧颞叶通道的患者。通道数与HFOs和发作频率无线性相关或趋势。大于20frs /min的通道数与癫痫发作频率呈线性正相关。产生hfo的组织越多，癫痫发作频率越高的假设尚未得到证实，尽管这可能与高FR率有关。(C) 2009 Elsevier B.V.版权所有
High frequency oscillations (HFOs) have been associated with epileptogenicity. In rats, the extent of HFOs (>200 Hz) is correlated with seizure frequency. We studied whether the same applies to patients with focal epilepsy. Thirty-nine patients with intracerebral EEG sampled at 2000 Hz were studied for interictal ripples (80-250 Hz), fast ripples (FR, 250-500 Hz) and spikes. Seizure frequency before implantation was compared to numbers of channels with HFOs (>1 /min). Analyses were repeated for HFO rates of >5, >10 and >20. Separate analyses were done for 25 patients with temporal lobe epilepsy only and for a selection of similar unilateral temporal channels in 12 patients. No linear correlation or trend was found relating the number of channels with HFOs and seizure frequency. There was a linear positive correlation between the number of channels with more than 20 FRs/min and seizure frequency. The hypothesis that the more tissue generating HFOs, the higher the seizure frequency, was not confirmed, though there might be a correlation for high FR rates. (C) 2009 Elsevier B.V. All rights reserved.