An international field study of the EORTC QLQ-PR25: A questionnaire for assessing the health-related quality of life of patients with prostate cancer
An international field study of the EORTC QLQ-PR25: A questionnaire for assessing the health-related quality of life of patients with prostate cancer
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DOI：
10.1016/j.ejca.2008.07.030
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发表时间：
2008-11-01
影响因子：
8.4
通讯作者：
Aaronson, Neil K.
中科院分区：
文献类型：
--
作者：
van Andel, George;Bottomley, Andrew;Aaronson, Neil K.
目标：为了评估EORTC QLQ-PR 25的心理测量学，一份评估前列腺癌患者健康相关生活质量的问卷。方法：对来自13个国家的642名前列腺癌患者进行QLQ-PR 25和QLQ-C30的心理测量学研究。QLQ-PR 25评估泌尿，肠道和性症状和功能，激素治疗的副作用。多特质量表分析证实了QLQ-PR 25的假设量表结构。泌尿系统症状和性功能量表的内部一致性信度良好（系数α = 0.70-0.86），但肠道功能和激素治疗副作用量表的内部一致性信度较低（α < 0.70）。该模块区分明确临床不同的患者亚组，并响应随着时间的推移在健康状况的变化。结论：在一般情况下，QLQ-PR 25表现出可接受的心理测量特性和临床有效性。在解释激素治疗量表的肠功能和副作用时应谨慎;结果可以在单个项目和量表水平上报告。(C)2008爱思唯尔有限公司保留所有权利。
Aim: To evaluate the psychometrics of the EORTC QLQ-PR25, a questionnaire assessing the health-related quality of life of prostate cancer patients.Methods: The QLQ-PR25 and the QLQ-C30 were administered to 642 prostate cancer patients from 13 countries treated with curative or palliative intent. The QLQ-PR25 assesses urinary, bowel and sexual symptoms and functioning, and the side-effects of hormonal treatment.Results: Five hundred and nine patients were available for the final analysis. Multitrait scaling analyses confirmed the hypothesised scale structure of the QLQ-PR25. Internal consistency reliability was good (coefficient alpha = 0.70-0.86) for the urinary symptoms and sexual function scales, but lower for the bowel function and side-effects of hormonal treatment scales (alpha < 0.70). The module discriminated clearly between clinically distinct patient subgroups, and was responsive to changes in health status over time.Conclusion: In general, the QLQ-PR25 demonstrates acceptable psychometric properties and clinical validity. Some caution should be used in interpreting the bowel function and side-effects of hormonal therapy scales; results can be reported at the individual item and scale level. (C) 2008 Elsevier Ltd. All rights reserved.