Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart:: A preliminary study
Correlation of in vivo clot deposition with the flow characteristics in the 50 cc Penn State Artificial Heart:: A preliminary study
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DOI：
10.1097/01.mat.0000145694.40637.a0
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发表时间：
2004-11-01
期刊：
影响因子：
4.2
通讯作者：
Deutsch, S
中科院分区：
文献类型：
--
作者：
Hochareon, P;Manning, KB;Deutsch, S
人工心脏的血流停滞可能提供血栓形成的条件。如果部分或全部血栓脱落，血栓栓塞可能导致中风、神经功能缺损，甚至死亡。为了确定是否存在低剪切或停滞状态，采用二维粒子图像测速（PIV）系统来测量50毫升宾夕法尼亚州立大学人工心脏内的速度场。速度测量值在最靠近壁面处进行分解，得到沿腔室底部的壁面剪切速率。PIV测量在腔室深度的三个图像平面上进行，以重建整个心脏周期底部壁面剪切率的表面分布。墙体剪切速率在空间上不均匀，墙体剪切速率持续较低。底部靠近腔室前缘的区域显示出壁面剪切速率不超过250 s（-1）。这是在体内观察到的血栓形成区域，提示低壁剪切率区与血栓形成之间可能存在联系。
Flow stasis in an artificial heart may provide a situation where thrombus develops. Should part, or all, of the clot dislodge, a thromboembolism may lead to stroke(s), neurologic deficits, or even death. In an effort to determine if the regime of low shear or stasis exists, a two-dimensional particle image velocimetry (PIV) system was implemented to measure the velocity field within the 50 cc Penn State Artificial Heart. The velocity measurements were decomposed nearest the wall to obtain wall shear rates along the bottom of the chamber. The PIV measurements were made in three image planes across the depth of the chamber to reconstruct a surface distribution of the wall shear rates at the bottom over the entire heart cycle. The wall shear rate is shown to be spatially nonuniform, with persistently low wall shear rates. An area near the front edge of the chamber at the bottom showed wall shear rates not exceeding 250 s(-1). This was an area of clot formation seen in vivo, suggesting a link may exist between the low wall shear rate zone and thrombus formation.