GATE CONTROL-THEORY OF PAIN MECHANISMS - RE-EXAMINATION AND RE-STATEMENT
GATE CONTROL-THEORY OF PAIN MECHANISMS - RE-EXAMINATION AND RE-STATEMENT
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DOI：
10.1093/brain/101.1.1
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发表时间：
1978-01-01
期刊：
影响因子：
14.5
通讯作者：
WALL, PD
中科院分区：
文献类型：
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作者：
WALL, PD
1965年，Melzack和我提出了一个门控制理论，后来我们修改和现代化的原始建议（Melzack，1973;墙，1973，1974，1976）。Nathan（1976）写了一篇详细的评论，其中他特别关注机制。在这里，我想扩展他的评论，以表明新知识需要修改我们以前的思想，理论现在站在哪里，我们的知识差距仍然阻止从投机到现实的运动。在我们最初的发言中，有些观点似乎被误解了，需要加以澄清。我们发表的机制图有所有的缺点，过于清晰，其重点是胶状质和突触前机制。该机构的文件提到其他可能的机制，但它似乎有些整个理论的基础上的图解机制，我们将看到的情况并非如此。当然，自1965年以来，有许多有趣的发现需要回顾。这些新的事实表明，一些理论所依据的数据是坦率的误导。最后，我们将试图说明技术的持续不足仍然阻碍了机制的阐明。
IN 1965, Melzack and I proposed a gate control theory and later we modified and modernized the original proposal (Melzack, 1973; Wall, 1973, 1974, 1976). Nathan (1976) has written a detailed review in which he concentrates particularly on mechanisms. Here I would like to extend his review to show where new knowledge requires a modification of our previous thinking, where the theory stands now and where gaps in our knowledge still prevent movement from speculation to reality. There were certain points in our original statement which seem to have been misunderstood and these need clarification. The diagram of mechanism we published had all the disadvantages of excessive clarity with its emphasis on the substantia gelatinosa and presynaptic mechanisms. The body of the paper mentioned other possible mechanisms but it has seemed to some that the entire theory rested on the diagrammatic mechanism which we shall see is not the case. Of course there have been many interesting discoveries since 1965 which need reviewing. X Some of these new facts show that the data on which some of the theory was based was frankly misleading. Finally we shall try to show where the persistent inadequacy of technique still prevents an elucidation of mechanism.