The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus
The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus
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DOI：
10.1016/j.virusres.2006.03.010
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发表时间：
2006-10-01
期刊：
影响因子：
5
通讯作者：
Takashima, Ikuo
中科院分区：
文献类型：
--
作者：
Shirato, Kazuya;Miyoshi, Hirotsugu;Takashima, Ikuo
西尼罗病毒（WN）纽约株的包膜（E）蛋白糖基化状态是病毒神经侵袭性的重要决定因素。为了阐明E蛋白糖基化和非糖基化WN病毒感染之间差异的决定因素，检测了感染每种病毒的小鼠腹腔巨噬细胞的细胞因子表达。肿瘤坏死因子（TNF）α和白细胞介素（IL）-1 β随着E蛋白糖基化病毒的复制而上调。随着两种病毒的清除，干扰素（IFN）β和IL-6上调。这些结果表明，TNF α和IL-1 β的表达与E蛋白糖基化WN病毒的毒力有关。(c)2006 Elsevier B. V.保留所有权利。
The envelope (E) protein glycosylation status of the New York strain of West Nile (WN) virus is an important determinant of virus neuroinvasiveness. To elucidate the determinant of the difference between E protein-glycosylated and non-glycosylated WN virus infections, the cytokine expression of murine peritoneal macrophages infected with each virus was examined. Tumor necrosis factor (TNF) alpha and interleukin (IL)-1 beta were up-regulated with replication of the E protein-glycosylated virus. Interferon (IFN) beta and IL-6 were up-regulated with the clearance of both viruses. These results suggest that TNF alpha and IL-1 beta expression are related to the virulence of E protein-glycosylated WN virus. (c) 2006 Elsevier B.V. All rights reserved.