Risk of periodontitis in systemic lupus erythematosus is associated with Fcγ receptor polymorphisms
Risk of periodontitis in systemic lupus erythematosus is associated with Fcγ receptor polymorphisms
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DOI：
10.1902/jop.2003.74.3.378
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发表时间：
2003-03-01
影响因子：
4.3
通讯作者：
Yoshie, H
中科院分区：
文献类型：
--
作者：
Kobayashi, T;Ito, S;Yoshie, H
背景资料：免疫球蛋白G的白细胞Fc受体（Fc γ R）在系统性红斑狼疮（SLE）和牙周炎中的免疫复合物和病原体的处理中起主要作用。这两种疾病已被证明是部分影响的遗传成分，包括Fc γ R基因型。因此，本研究的目的是评估FcgammaR基因多态性是否与牙周炎的风险SLE patients.Methods：研究对象包括42例SLE患者牙周炎（SLE/P），18例SLE患者没有牙周炎（SLE/H），42例健康受试者牙周炎（H/P），和42例健康受试者没有牙周炎（H/H），谁都无关的日本非吸烟者。结果：SLE/P组牙周组织破坏程度明显轻于H/P组（P < 0.01）; SLE/P组与H/H组Fc γ RIIa基因型分布差异有统计学意义（P = 0.004）。与H/H组相比，在SLE/P组中发现Fc γ RIIa-R131等位基因的显著过度表达（SLE/P vs H/H：比值比[OR] 3.13，95%置信区间[CI] 1.46-6.77，P = 0.0013）。此外，牙周炎的患病率被发现是70%的SLE患者。与SLE/H组相比，SLE/P组中Fc γ RIIa-R131等位基因的检出率更高（SLE/P vs. SLE/H：OR 3.40，95%CI 1.18-10.25，P = 0.011）。
Background: Leukocyte Fc receptors for immunoglobulin G (FcgammaR) play a major role in the handling of immune complexes and pathogens in systemic lupus erythematosus (SLE) and periodontitis. Both diseases have been shown to be partly influenced by genetic components including FcgammaR genotype. The aim of this study was therefore to evaluate whether FcgammaR gene polymorphisms are associated with periodontitis risk in SLE patients.Methods: The study subjects consisted of 42 SLE patients with periodontitis (SLE/P), 18 SLE patients without periodontitis (SLE/H), 42 healthy subjects with periodontitis (H/P), and 42 healthy subjects without periodontitis (H/H), who were all unrelated Japanese non-smokers. Genomic DNA was isolated from peripheral blood, and FcgammaR genotypes for 3 biallelic polymorphisms (FcgammaRIIa-R131/H131, FcgammaRIIIa-158V/158F, FcgammaRIIIb-NA1/NA2) were determined by allele-specific polymerase chain reactions.Results: The SLE/P group was found to have more mild levels of periodontal destruction than the H/P group (P < 0.01). There was a significant difference in the distribution of FcgammaRIIa genotypes between SLE/P and H/H groups (P = 0.004). A significant overrepresentation of the FcgammaRIIa-R131 allele was found in the SLE/P group compared to the H/H group (SLE/P versus H/H: odds ratio [OR] 3.13, 95% confidence interval [CI] 1.46-6.77, P = 0.0013). Furthermore, the prevalence of periodontitis was found to be 70% in SLE patients. The FcgammaRIIa-R131 allele was also found to be overrepresented in the SLE/P group compared to the SLE/H group (SLE/P versus SLE/H: OR 3.40, 95% CI 1.18-10.25, P = 0.011).Conclusion: These results show the FcgammaRIIa-R131 allele to be associated with periodontitis risk in SLE patients.