Heme oxygenase 1 is required for mammalian iron reutilization
Heme oxygenase 1 is required for mammalian iron reutilization
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DOI：
10.1073/pnas.94.20.10919
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发表时间：
1997-09-30
影响因子：
11.1
通讯作者：
Tonegawa, S
中科院分区：
文献类型：
--
作者：
Poss, KD;Tonegawa, S
用于必需的哺乳动物生物学活动如红细胞生成的大部分铁被认为是从细胞血红素蛋白中再利用的。在这里，我们产生了缺乏功能性血红素加氧酶1（Hmox 1; EC 1.14.99.3）的小鼠，其将血红素分解代谢为胆绿素、一氧化碳和游离铁，以评估其在铁稳态中的参与。Hmox 1缺陷的成年小鼠发展出与异常低血清铁水平相关的贫血，然而，肝和肾铁积累，导致大分子氧化损伤，组织损伤和慢性炎症，我们的研究结果表明，Hmox 1具有重要的再循环作用，通过促进铁从肝和肾细胞的释放，并描述了人类铁代谢紊乱的小鼠模型。
The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins, Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis, Hmox1-deficient adult mice developed an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iron that contributed to macromolecular oxidative damage, tissue injury, and chronic inflammation, Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.