Medical management of organophosphate-induced seizures
Medical management of organophosphate-induced seizures
复制标题
DOI：
10.1016/s0928-4257(99)80007-2
复制
发表时间：
1998-10-01
影响因子：
--
通讯作者：
Blanchet, G
中科院分区：
文献类型：
--
作者：
Lallement, G;Dorandeu, F;Blanchet, G
最近的研究有关梭曼诱导的癫痫发作的管理。虽然在医院中用于治疗癫痫的经典药物对梭曼似乎无效，但毒蕈碱受体阻滞剂显示能够在发作后的前5分钟内预防或停止癫痫发作。苯二氮卓类也可以被认为是一种紧急治疗有用的癫痫发作的第一个10分钟。比较而言，NMDA拮抗剂似乎能够终止梭曼诱导的癫痫发作，即使治疗延迟40分钟后的癫痫活动。具有抗毒蕈碱和抗NMDA特性的药物可能是治疗梭曼中毒的最适当的药物治疗。然而，迄今为止用这些药物获得的结果必须与它们在肌内注射后的可能疗效相关。局对未来研究的建议进行了综述。((C)Elsevier，巴黎）。
Recent studies concerning management of soman-induced seizures are reviewed. While drugs classically used against epilepsy in hospital appear ineffective against soman, muscarinic receptor blockers are shown to be able to prevent or stop seizures within the first 5 min after their onset. Benzodiazepine could also be considered as an emergency treatment useful during the first 10 min of seizure. Comparatively NMDA antagonists appear to be able to terminate soman-induced seizures even if the treatment is delayed after 40 min of epileptic activity. Drugs with both antimuscarinic and anti-NMDA properties may represent the most adequate pharmacological treatment to treat soman intoxication. However, the results obtained until now with these drugs must be completed in relation with their possible efficacy after i.m. administration. Propositions for future studies are reviewed. ((C) Elsevier, Paris).