Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo
Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo
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DOI：
10.1002/ijc.1519
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发表时间：
2001-12-01
影响因子：
6.4
通讯作者：
Bach, LA
中科院分区：
文献类型：
--
作者：
Gallicchio, MA;Kneen, M;Bach, LA
Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood. Rhabdomyosarcoma cell lines overexpress insulin-like growth factor-II (IGF-II), an autocrine growth factor that is inhibited by insulin-like growth factor binding protein-6 (IGFBP-6). IGFBP-6 is associated with myoblast quiescence, and expression in rhabdomyosarcoma cells is low. The effect of IGFBP-6 on 2 rhabdomyosarcoma cell lines, RD and Rh30, was studied. IGFBP-6 inhibited anchorage-dependent growth of RD and Rh30 cells in a dose-dependent manner (p
