Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders
Abnormal cell patterning at the cortical gray-white matter boundary in autism spectrum disorders
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DOI：
10.1016/j.brainres.2010.08.091
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发表时间：
2010-11-11
期刊：
影响因子：
2.9
通讯作者：
Hutsler, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Avino, Thomas A.;Hutsler, Jeffrey J.
先前关于神经元间距和柱状组织的研究表明，自闭症谱系障碍（ASD）患者的大脑皮层中存在细胞模式改变。这些模式异常包括灰质边界的不规则性，可能涉及早期神经发育事件，如改变ASD皮层组织的迁移。本研究采用了一种新的方法来量化8名ASD和8名典型发展对照组的灰质-白质边界。在每个病例的颞上肌（BA21）、背外侧额叶（BA9）和背顶叶（BA7）的多个位置获得了灰质边界的数码显微照片。在第六层与下卧白质（底板）之间的过渡区拟合了一条s形曲线，所得曲线的斜率作为过渡区的空间范围的度量。对于所有三个皮质区域的检查，ASD受试者的s型曲线与神经正常者相比“较浅”，这表明皮层第六层和底层白质之间存在模糊的边界。这些结果可能反映了皮层板下存在多余的神经元，这可能是板下区域迁移缺陷或凋亡失败的结果。此外，这些发现提出了关于依赖灰质分割的皮层测量的有效性的问题，因为模糊的过渡区可能导致皮质边界错位和厚度和体积测量的错误。(C) 2010 Elsevier B.V.版权所有
Previous research on neuronal spacing and columnar organization indicates the presence of cell patterning alterations within the cerebral cortex of individuals with autism spectrum disorders (ASD). These patterning abnormalities include irregularities at the gray-white matter boundary and may implicate early neurodevelopmental events such as migration in altering cortical organization in ASD. The present study utilized a novel method to quantify the gray-white matter boundary in eight ASD and eight typically developing control subjects. Digital photomicrographs of the gray-white matter boundary were acquired from multiple positions within the superior temporal gyms (BA21), dorsolateral frontal lobe (BA9), and dorsal parietal lobe (BA7) of each case. A sigmoid curve was fitted to the transition zone between layer VI and underlying white matter (subplate), and the slope of the resulting curve was used as a measure of the spatial extent of the transition zone. For all three cortical regions examined, ASD subjects showed "shallower" sigmoid curves compared to neurotypicals, indicating the presence of an indistinct boundary between cortical layer VI and the underlying white matter. These results may reflect the presence of supernumerary neurons beneath the cortical plate that could be the result of migration deficits or failed apoptosis in the subplate region. Furthermore, these findings raise questions regarding the validity of cortical measures that rely on gray-white matter parcellation, since an indistinct transition zone could lead to a misplaced cortical boundary and errors in both thickness and volume measures. (C) 2010 Elsevier B.V. All rights reserved.