Comprehensive identification of mutational cancer driver genes across 12 tumor types
Comprehensive identification of mutational cancer driver genes across 12 tumor types
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DOI：
10.1038/srep02952
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发表时间：
2013-10-02
影响因子：
4.6
通讯作者：
Lopez-Bigas, Nuria
中科院分区：
文献类型：
--
作者：
Tamborero, David;Gonzalez-Perez, Abel;Lopez-Bigas, Nuria
有了对肿瘤基因组/外显子组进行完整测序的能力，对癌症驱动基因的探索现在可以以公正的方式进行。然而，由于疾病的异质性分子性质和现有计算方法的局限性，获得完整的癌症基因目录是困难的。在这里，我们展示了互补方法的组合可以确定一个全面和可靠的癌症驱动基因列表。我们提供了291个高可信度的癌症驱动基因的列表，这些基因作用于来自12种不同癌症类型的3,205个肿瘤。在这些基因中，有些以前没有被确定为癌症驱动因素，16种明显倾向于维持一种特定肿瘤类型的突变。新的候选驱动因素补充了我们目前对这些疾病出现的认识。总之，驱动基因的目录和本文提出的方法为更好地理解肿瘤发生机制开辟了新的途径。
With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous molecular nature of the disease and the limitations of available computational methods. Here we show that the combination of complementary methods allows identifying a comprehensive and reliable list of cancer driver genes. We provide a list of 291 high-confidence cancer driver genes acting on 3,205 tumors from 12 different cancer types. Among those genes, some have not been previously identified as cancer drivers and 16 have clear preference to sustain mutations in one specific tumor type. The novel driver candidates complement our current picture of the emergence of these diseases. In summary, the catalog of driver genes and the methodology presented here open new avenues to better understand the mechanisms of tumorigenesis.