Response to acute psychophysical stress and 24-hour glycemic control in healthy older people.
Response to acute psychophysical stress and 24-hour glycemic control in healthy older people.
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健康老年人对急性心理物理压力的反应和 24 小时血糖控制。
DOI：
10.1155/2012/803864
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发表时间：
2012
影响因子：
4.7
通讯作者：
Gribok,Andrei
中科院分区：
文献类型：
--
作者：
Dipietro,Loretta;Yeckel,CatherineW;Gribok,Andrei
我们研究了17名不活动的健康老年人（≥60岁）在新的心理物理应激和坐位对照条件下应激反应性与24小时血糖控制的关系。在应激和恢复期测量血浆皮质醇。在随后的3小时内，通过口服葡萄糖耐量试验（OGTT）和超过24小时的连续血糖监测（CGM）来确定血糖控制。我们观察到，与对照组相比，应激期间，感知应激、心血管活动和30min时皮质醇峰值反应（10.6±3.1比8.6±2.6μg·dL−1，分别为）显著（P< 0.05）升高；然而，3小时OGTT血糖和胰岛素反应在两种情况下是相似的。CGM数据显示，应激条件下，葡萄糖峰值反应延迟30-40分钟，葡萄糖清除在应激条件下的6小时内减弱，但这些变化没有统计学意义。健康的老年人在日常心理压力后可能表现出代谢弹性的最小破坏。
We examined the relation between stress reactivity and 24 h glycemic control in 17 inactive, healthy older people (≥60 years) under both a novel psychophysical stress and a seated control condition. Plasma cortisol was measured over the course of the stress and recovery periods. Glycemic control was determined over the subsequent 3 h from an oral glucose tolerance test (OGTT) and over 24 hviacontinuous glucose monitoring (CGM). We observed significant (P< 0.05) elevations in perceived stress, cardiovascular activity, and peak cortisol response at 30 min (10.6 ± 3.1 versus 8.6 ± 2.6μg·dL−1, resp.) during the stress compared with the control condition; however, 3 h OGTT glucose and insulin responses were similar between conditions. The CGM data suggested a 30–40 min postchallenge delay in peak glucose response and attenuated glucose clearance over the 6 h following the stress condition, but these alterations were not statistically significant. Healthy older people may demonstrate minimal disruption in metabolic resiliency following everyday psychological stress.