Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
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DOI：
10.1016/j.bbrc.2010.02.173
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发表时间：
2010-05-21
影响因子：
3.1
通讯作者：
Samuelsson, Bengt
中科院分区：
文献类型：
--
作者：
Radmark, Olof;Samuelsson, Bengt
5-脂氧合酶（5LO）催化白三烯（LT）生物合成中的两个步骤，白三烯是花生四烯酸衍生的炎症脂质介质。LT在正常的宿主防御中起作用，并且在慢性炎症性疾病如哮喘和动脉粥样硬化中具有病理生理学作用。此外，已经描述了与肿瘤发生有关的5LO产物的可能作用。因此，关于5LO的生物化学的见解与更好地理解正常生理学和开发治疗相关。(C)2010年爱思唯尔公司All rights reserved.
5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO products in relation to tumorigenesis have been described. Thus, insight regarding the biochemistry of 5LO is relevant for better understanding of normal physiology, and for development of therapy. (C) 2010 Elsevier Inc. All rights reserved.