Female temperament, tumor development and life span:: Relation to glucocorticoid and tumor necrosis factor α levels in rats
Female temperament, tumor development and life span:: Relation to glucocorticoid and tumor necrosis factor α levels in rats
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DOI：
10.1016/j.bbi.2007.10.014
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发表时间：
2008-07-01
影响因子：
15.1
通讯作者：
Klein, Laura Cousino
中科院分区：
文献类型：
--
作者：
Cavigelli, Sonia A.;Bennett, Jeanette M.;Klein, Laura Cousino
与特定生理特征密切相关的行为特征是理解健康差异的重要研究领域。特别是，糖皮质激素过量产生可能是减缓疾病进展的重要因素；这种类固醇产生的自然差异已被认为是健康和疾病个体差异的一种机制。在本文中，我们检查了两种不同行为类型的雌性大鼠的免疫参数，先前显示这两种行为类型具有不同的糖皮质激素产生和寿命。我们根据年轻雌性大鼠对新奇事物的行为反应（高或低运动）对其进行分类，并比较它们的糖皮质激素产生、肾上腺大小、胸腺大小、肿瘤坏死因子-α (TNF-α) 产生、肿瘤发展和寿命。正如预期的那样，高运动雌性在成年早期比低运动雌性产生更多的糖皮质激素并且具有更大的肾上腺。与低运动能力的雌性相比，高运动能力的雌性胸腺明显较小，TNF-α水平也较低，这表明成年早期的免疫功能发生了改变。最后，高运动女性的寿命比低运动女性的寿命短，这在患有垂体肿瘤的女性中尤其如此，但在那些患有乳腺肿瘤的女性中则不然。这些结果以及其他已发表的研究结果表明，高运动雌性啮齿类动物对新奇事物的糖皮质激素反应终生都会升高，并且这些升高的水平可能与慢性压力相当。这种自然发生的内分泌特征可能会影响免疫反应，进而影响疾病的易感性。不同性格类型之间免疫功能的差异可能部分受到糖皮质激素产生的自然差异的调节。由爱思唯尔公司出版
Behavioral characteristics closely associated with specific physiological profiles present art important area of research in understanding health disparities. In particular, glucocorticoid overproduction may be an important factor moderating disease progression; natural variance in production of this steroid has been proposed as one mechanism underlying individual differences in health and disease. In the current paper, we examined immune parameters in female rats of two different behavioral types previously shown to have differential glucocorticoid production and life spans. We categorized young female rats according to their behavioral response to novelty (high or low-locomotion), and compared their glucocorticoid production, adrenal size, thymus size, tumor necrosis factor-alpha (TNF-alpha) production, tumor development and life span. As expected, high-locomotion females produced more glucocorticoids and had larger adrenal glands during young adulthood than did low-locomotion females. High-locomotion females had significantly smaller thymuses and reduced TNF-alpha levels compared to low-locomotion, suggesting altered immune function in young adulthood. Finally, high-locomotion females had shorter life spans than did low-locomotion females, and this was particularly true in females that developed pituitary tumors, but not in those that developed mammary tumors. These results, along with other published findings, suggest that high-locomotion rodent females experience life-long elevations in glucocorticoid responses to novelty, and that these elevated levels may be comparable to chronic stress. This naturally occurring endocrine profile may influence immune responses which in turn could affect disease susceptibility. Variance in immune function across personality types may be partially moderated by natural variance in glucocorticoid production. Published by Elsevier Inc.