Understanding osteosarcomas
Understanding osteosarcomas
复制标题
DOI：
10.1097/01.jaa.0000541477.24116.8d
复制
发表时间：
2018-08-01
影响因子：
1.1
通讯作者：
Brown, Heather L.
中科院分区：
文献类型：
--
作者：
Simpson, Emily;Brown, Heather L.
骨肉瘤是儿童和青少年中最常见的原发性骨肿瘤，也是第三常见的癌症。在20世纪70年代，肿瘤切除术后辅助化疗的引入将患者的总体10年生存率从30%提高到约50%。然而，自从管理策略发生变化以来，生存率一直处于稳定状态，自20世纪90年代以来，总体10年生存率没有改善。更好地了解这种疾病是帮助改善这些数字的第一步。
This article reviews the cause, clinical presentation, diagnostic methods, and management of osteosarcoma, the most common primary bone tumor and third most common cancer among children and adolescents. In the 1970s, the introduction of adjuvant chemotherapy following tumor resection improved overall 10-year survival from 30% to about 50% of patients. However, since that change in management strategy, the survival rate has since plateaued, with no improvement in overall 10-year survival since the 1990s. A better understanding of this disease is the first step to help improve these numbers.