Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
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DOI：
10.1038/jhg.2009.106
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发表时间：
2009-12-01
影响因子：
3.5
通讯作者：
Nakamura, Yusuke
中科院分区：
文献类型：
--
作者：
Hotta, Kikuko;Nakamura, Michihiro;Nakamura, Yusuke
有证据表明，高加索人群中的肥胖表型与几种基因的变异有关，包括神经元生长调节因子1（NEGR 1）、SEC 16同源物B（SCE 16 B）、跨膜蛋白18（TMEM 18）、ets变体5（ETV 5）、葡糖胺-6-磷酸脱氨酶2（GNPDA 2）、催乳素（PRL）、脑源性神经营养因子（BDNF）、线粒体载体同源物2（MTCH 2）、Fas凋亡抑制分子2（FAIM 2）、SH 2B衔接蛋白1（SH 2B 1）、v-maf肌肉腱膜纤维肉瘤癌基因同源物（MAF）、尼曼-皮克病（Niemann-Pick disease）、C1型（NPC 1）、黑素皮质素4受体（MC 4 R）和含钾通道四聚化结构域15（KCTD 15）。为了研究日本人群中肥胖与这些基因的关系，我们对肥胖受试者（n=1129，体重指数（BMI）≥ 30 kg/m（-2））和正常体重对照受试者（n=1736，BMI）的14个基因中的27个单核苷酸多态性（SNP）进行了基因分型
There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) >= 30 kg m(-2)) and normal-weight control subjects (n=1736, BMI