Dietary zinc and prostate cancer in the TRAMP mouse model.
Dietary zinc and prostate cancer in the TRAMP mouse model.
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DOI：
10.1089/jmf.2009.0042
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发表时间：
2010-02
影响因子：
2.4
通讯作者：
Kucuk O
中科院分区：
文献类型：
--
作者：
Prasad AS;Mukhtar H;Beck FW;Adhami VM;Siddiqui IA;Din M;Hafeez BB;Kucuk O
环境证据表明，锌可能在前列腺中起重要作用。前列腺中的总锌水平比其他软组织高10倍。前列腺上皮癌细胞中锌浓度显著降低。补锌对预防和治疗人类前列腺癌的影响产生了争议的结果。迄今为止，还没有动物模型研究报告显示补锌对预防前列腺癌的影响。在这项研究中，我们研究了锌补充剂对TRAMP小鼠模型前列腺癌发展的影响。我们的研究结果表明，饮食锌在前列腺癌的发生中起着重要的作用。当膳食锌摄入量不足或高于正常锌摄入量水平时，肿瘤重量显著较高，表明最佳膳食锌摄入量可能对前列腺癌起保护作用。此外，我们的研究还表明，在正常的锌补充动物中，IGF-1和IGF-1/IGFBP-3比值降低，表明锌可能调节IGF-1代谢与致癌作用有关。我们得出结论，最佳的前列腺锌浓度对癌症有保护作用。
Circumstantial evidences indicate that zinc may have an important role in the prostate. Total zinc levels in the prostate are 10 times higher than in other soft tissues. Zinc concentration in prostate epithethial cancer cells are decreased significantly. Effect of zinc supplementation on prevention and treatment of prostate cancer in humans have yielded controversial results. No studies have been reported in animal models to show the effect of zinc supplementation on prevention of prostatic cancer, thus far. In this study, we have examined the effect of zinc supplementation on development of prostatic cancer in a TRAMP mouse model. Results from our study indicate that dietary zinc plays an important role in prostate carcinogenesis. Tumor weights were significantly higher when the dietary zinc intake was either deficient or high in comparison to normal zinc intake level, suggesting that an optimal dietary zinc intake may play a protective role against prostate cancer. Further, our studies also showed decreased IGF-1 and IGF-1/IGFBP-3 ratio in normal zinc supplemented animals, suggesting that zinc may modulate IGF-1 metabolism in relation to carcinogenesis. We conclude that optimal prostate zinc concentration has a protective role against cancer.
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影响因子：
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