Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus
Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus
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DOI：
10.1080/09513590.2020.1780579
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发表时间：
2020-06-19
影响因子：
2
通讯作者：
Yu, Qing
中科院分区：
文献类型：
--
作者：
Liu, Wenhua;Lou, Xiangming;Yu, Qing
目的：本研究旨在探讨中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、平均血小板体积与妊娠期糖尿病风险的相关性。研究方法：选择妊娠24、28周的孕妇120例，其中GDM组58例，对照组62例。测量NLR、PLR和MPV水平。结果：GDM组NLR、PLR、MPV均显著高于对照组。Logistic回归分析显示，WBC、NLR、PLR和MPV升高是妊娠期GDM的独立预测变量。OR和95%CI分别为（OR：1.6，95%CI：1.2-2.5），（OR：4.1，95%CI：1.3-13.1），（OR：5.5，95%CI：1.5-20.0），（OR：4.0，95%CI：1.2-12.0）。结论：WBC、PLR、NLR、MPV升高是GDM的独立预测因子。
Objective: In the present study, we aimed to investigate the correlation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume with the risk of gestational diabetes mellitus. Methods: The study enrolled 120 pregnant women who were the 24th and 28th weeks of gestation, including GDM group (n = 58), the control group (n = 62). The NLR, PLR and MPV levels were measured. Results: NLR, PLR and MPV were significantly higher in GDM compared with control group. Logistic regression analysis showed that elevated WBC, NLR, PLR and MPV was an independent variable for predicting GDM in pregnancy. The OR and 95% CI was (OR: 1.6, 95% CI: 1.2-2.5), (OR: 4.1, 95% CI: 1.3-13.1), (OR: 5.5, 95% CI: 1.5-20.0), (OR: 4.0, 95% CI: 1.2-12.0), respectively. Conclusion: Increased WBC, PLR, NLR, MPV were independent predictors of GDM.