THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE.
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获得的细胞抗性的免疫学基础。
DOI：
10.1084/jem.120.1.105
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发表时间：
1964-07-01
影响因子：
15.3
通讯作者：
MACKANESS, G B
中科院分区：
文献类型：
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作者：
MACKANESS, G B
小鼠在感染单核细胞增生性李斯特氏菌、流产布鲁氏菌或结核分枝杆菌期间产生的抵抗力并不是专门针对感染机体的。然而，诱导获得性抗性的过程是高度特异的，似乎取决于两个因素：宿主的免疫反应性状态和宿主对其产生反应的特定微生物抗原的存在。当这两种细菌同时存在于组织中时，宿主被发现是非特异性抗性的。结果表明，这种依赖于宿主巨噬细胞状态改变的抗性可能是由于抗原和吸附在宿主巨噬细胞表面的特异性抗体的相互作用所致，参与反应的抗体可能与导致迟发型超敏状态的抗体相同。关于潜伏感染和感染免疫的问题，讨论了结果。
The resistance developed by mice during infection with Listeria monocytogenes, Brucella abortus, or Mycobacterium tuberculosis is not specifically directed against the infecting organism. The processes involved in the induction of acquired resistance, however, are highly specific and seem to depend upon two factors: a state of immunological reactivity of the host and the presence of the specific microbial antigens to which the host has become reactive. When these two coexist in the tissues the host is found to be non-specifically resistant. It is suggested that resistance, which was shown to depend upon an altered state of host macrophages, may be due to the interaction of antigen and a specific antibody adsorbed to the surface of host macrophages; and that the antibody involved in the reaction is perhaps identical with the antibody which confers the state of delayed-type hypersensitivity. The results are discussed in relation to the question of latent infection and infection immunity.