Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.
Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.
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DOI：
10.1016/j.virol.2013.04.009
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发表时间：
2013-08
期刊：
影响因子：
3.7
通讯作者：
Rongrong Zhai;Ai-Ping Jiang;Hai-Bo Wang;L. Ma;Xiao-Xin Ren;Jin-Feng Jiang;Li Wu;Ji-Fu Wei;Jian-Hua Wang
中科院分区：
文献类型：
--
作者：
Rongrong Zhai;Ai-Ping Jiang;Hai-Bo Wang;L. Ma;Xiao-Xin Ren;Jin-Feng Jiang;Li Wu;Ji-Fu Wei;Jian-Hua Wang
Altered cytokine profiles and imbalanced frequencies of CD4+T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.
