High-Precision Stereolithography of Biomicrofluidic Devices
High-Precision Stereolithography of Biomicrofluidic Devices
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DOI：
10.1002/admt.201800395
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发表时间：
2019-06-01
影响因子：
6.8
通讯作者：
Folch, Albert
中科院分区：
文献类型：
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作者：
Kuo, Alexandra P.;Bhattacharjee, Nirveek;Folch, Albert
光固化快速成型技术以其低成本、高效率的优点成为软光刻技术的替代品。低分子量聚（乙二醇）二丙烯酸酯（MW = 258）（PEG-DA-258）已用于生物相容性微器件的亚毫米分辨率SL 3D打印。然而，同时具有高透明度，高生物相容性和高分辨率的3D打印树脂仍然缺乏。发现光敏剂异丙基噻吨酮可以以浓度依赖性方式使树脂（含有PEG-DA-258和光引发剂Irgacure-819）的吸光度增加一个数量级以上。这种吸光度的增加允许使用市售台式打印机以亚像素分辨率SL打印微型器件，而不会损害透明度或生物相容性。免组装、快速（
Stereolithography (SL) is emerging as an attractive alternative to soft lithography for fabricating microfluidic devices due to its low cost and high design efficiency. Low molecular weight poly(ethylene glycol)diacrylate (MW = 258) (PEG-DA-258) has been used for SL 3D-printing of biocompatible microdevices at submillimeter resolution. However, 3D-printing resins that simultaneously feature high transparency, high biocompatibility, and high resolution are still lacking. It is found that photosensitizer isopropyl thioxanthone can, in a concentration-dependent manner, increase the absorbance of the resin (containing PEG-DA-258 and photoinitator Irgacure-819) by over an order of magnitude. This increase in absorbance allows for SL printing of microdevices at sub pixel resolution with commercially available desktop printers and without compromising transparency or biocompatibility. The assembly-free, rapid (